Phosphatidic acid: from pleiotropic functions to neuronal pathology

E Tanguy, Q Wang, H Moine, N Vitale - Frontiers in cellular …, 2019 - frontiersin.org
Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a
key building block of phospholipid synthesis and a major lipid second messenger conveying …

Phosphatidic acid–a simple phospholipid with multiple faces

J Zegarlinska, M Piaścik, AF Sikorski… - Acta Biochimica …, 2018 - abp.ptbioch.edu.pl
Phosphatidic acid (PA) is the simplest glycerophospholipid naturally occurring in living
organisms, and even though its content among other cellular lipids is minor, it is drawing …

Phosphatidic acid in neuronal development: a node for membrane and cytoskeleton rearrangements

MR Ammar, N Kassas, MF Bader, N Vitale - Biochimie, 2014 - Elsevier
Phosphatidic acid (PA) is the simplest phospholipid naturally existing in all-living organisms.
It constitutes only a minor fraction of the total cell lipids but has attracted considerable …

Regulation of membrane turnover by phosphatidic acid: cellular functions and disease implications

R Thakur, A Naik, A Panda, P Raghu - Frontiers in Cell and …, 2019 - frontiersin.org
Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an
intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has …

Phosphatidic acid: an emerging versatile class of cellular mediators

SC Kim, X Wang - Essays in Biochemistry, 2020 - portlandpress.com
Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Phosphatidic acid: From biophysical properties to diverse functions

H Zhou, Y Huo, N Yang, T Wei - The FEBS Journal, 2024 - Wiley Online Library
Phosphatidic acid (PA), the simplest phospholipid, acts as a key metabolic intermediate and
second messenger that impacts diverse cellular and physiological processes across species …

Phosphatidic acid-mediated signaling

Y Liu, Y Su, X Wang - Lipid-mediated protein signaling, 2013 - Springer
Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular
PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions …

Putting the pH into phosphatidic acid signaling

JJH Shin, CJR Loewen - BMC biology, 2011 - Springer
The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic
regulation in all organisms. New evidence indicates that PA also has an unprecedented role …

Messenger functions of phosphatidic acid

D English, Y Cui, RA Siddiqui - Chemistry and physics of lipids, 1996 - Elsevier
Under physiological conditions, phosphatidic acid (PA) is an anionic phospholipid with
moderate biological reactivity. Some of its biological effects can be attributed to lyso-PA and …

Biological effects of lysophosphatidic acid in the nervous system

F Frisca, RA Sabbadini, Y Goldshmit… - International review of cell …, 2012 - Elsevier
Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular
effects in various cell types, leading to a variety of responses in tissues, including in the …