[HTML][HTML] Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin …

J Wang, T Wu, L Fang, C Liu, X Liu, H Li, J Shi… - Journal of Functional …, 2020 - Elsevier
In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and
identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS …

Peptides from walnut (Juglans mandshurica Maxim.) protect hepatic HepG2 cells from high glucose-induced insulin resistance and oxidative stress

J Wang, T Wu, L Fang, C Liu, X Liu, H Li, J Shi, M Li… - Food & function, 2020 - pubs.rsc.org
Oxidative stress is an important factor in the pathogenesis of insulin resistance (IR) in type 2
diabetes mellitus (T2DM). Bioactive peptides from nuts have been shown to alleviate …

Walnut-derived peptides promote autophagy via the activation of AMPK/mTOR/ULK1 pathway to ameliorate hyperglycemia in type 2 diabetic mice

W Hou, F Zhao, L Fang, X Wang, D Wu… - Journal of Agricultural …, 2023 - ACS Publications
Autophagy flux plays a significant protective role in type 2 diabetes mellitus (T2DM).
However, the mechanisms by which autophagy mediates insulin resistance (IR) to …

Gamma-conglutin peptides from Andean lupin legume (Lupinus mutabilis Sweet) enhanced glucose uptake and reduced gluconeogenesis in vitro

EB Muñoz, DA Luna-Vital, M Fornasini… - Journal of Functional …, 2018 - Elsevier
The present study aimed to analyze the mechanism of action of a hydrolyzed gamma-
conglutin fraction (Cgh) extracted from Andean L. mutabilis legume on glucose metabolism …

Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats

Y Zhang, C Ren, G Lu, Z Mu, W Cui, H Gao… - International …, 2014 - Elsevier
Diabetes mellitus is a clinically complex disease characterized by chronic hyperglycemia
with metabolic disturbances. In this study, we investigated the effect of mulberry leaf …

Effect of walnut meal peptides on hyperlipidemia and hepatic lipid metabolism in rats fed a high-fat diet

XY Yang, DY Zhong, GL Wang, RG Zhang, YL Zhang - Nutrients, 2021 - mdpi.com
As a natural active substance that can effectively improve blood lipid balance in the body,
hypolipidemic active peptides have attracted the attention of scholars. In this study, the effect …

Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High‐Fat via Activation of PI3K/AKT Signaling

Y Yang, W Li, Y Li, Q Wang, L Gao… - Oxidative medicine and …, 2014 - Wiley Online Library
Lycium barbarum polysaccharide (LBP), an antioxidant from wolfberry, displays the
antioxidative and anti‐inflammatory effects on experimental models of insulin resistance in …

Novel anti-obesity peptide (RLLPH) derived from hazelnut (Corylus heterophylla Fisch) protein hydrolysates inhibits adipogenesis in 3T3-L1 adipocytes by regulating …

J Wang, M Zhou, T Wu, L Fang, C Liu, W Min - Journal of Bioscience and …, 2020 - Elsevier
Highlights•A novel pentapeptide RLLPH was obtained from hazelnut hydrolysates.•RLLPH
inhibited the expression of adipogenesis-related factors and enzymes.•RLLPH up-regulated …

Purification and identification of a novel antidiabetic peptide from Chinese giant salamander (Andrias davidianus) protein hydrolysate against α-amylase and α …

AH Ramadhan, T Nawas, X Zhang… - … journal of food …, 2017 - Taylor & Francis
This study aimed to purify and identify a novel antidiabetic peptides from Chinese giant
salamander (Andrias davidianus) protein hydrolysate and to evaluate its anti-diabetic …

Molecular mechanism for the α-glucosidase inhibitory effect of wheat germ peptides

W Liu, H Li, Y Wen, Y Liu, J Wang… - Journal of Agricultural and …, 2021 - ACS Publications
Wheat germ peptides (WGPs) have various benefits to human health, while their
antidiabetes mechanism remains unknown. In this study, the α-glucosidase inhibition activity …