Conjugation of isoniazid to a zinc phthalocyanine via hydrazone linkage for pH-dependent liposomal controlled release
CI Nkanga, RWM Krause - Applied Nanoscience, 2018 - Springer
Tuberculosis (TB) remains the leading cause of mortality from infectious diseases. Extended
TB treatment and frequent adverse effects, due to poor bioavailability of anti-tubercular …
TB treatment and frequent adverse effects, due to poor bioavailability of anti-tubercular …
[HTML][HTML] Encapsulation of isoniazid-conjugated phthalocyanine-in-cyclodextrin-in-liposomes using heating method
CI Nkanga, RWM Krause - Scientific reports, 2019 - nature.com
Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-
tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis …
tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis …
pH-Dependent release of isoniazid from isonicotinic acid (4-hydroxy-benzylidene)-hydrazide loaded liposomes
Liposomes are considered as potential vehicles for the delivery of anti-tuberculosis drugs
(ATBD) due to their rapid uptake by alveolar macrophages, where the mycobacterium often …
(ATBD) due to their rapid uptake by alveolar macrophages, where the mycobacterium often …
Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate
Isoniazid (INH) is a first line drug for treatment of the widespread deadly disease caused by
Mycobacterium tuberculosis. Peptide conjugate of INH was designed and synthesised for …
Mycobacterium tuberculosis. Peptide conjugate of INH was designed and synthesised for …
Co-loading of isoniazid-grafted phthalocyanine-in-cyclodextrin and rifampicin in crude soybean lecithin liposomes: Formulation, spectroscopic and biological …
An inclusion complex of isoniazid-grafted phthalocyanine with gamma-cyclodextrin
(Complex) was co-encapsulated with rifampicin (RIF) in crude soybean lecithin liposomes …
(Complex) was co-encapsulated with rifampicin (RIF) in crude soybean lecithin liposomes …
Pulmonary delivery of anti-tubercular drugs using ligand anchored pH sensitive liposomes for the treatment of pulmonary tuberculosis
Background: Mycobacterium tuberculosis (M. TB) remains the prime cause of bacterial
mortality and morbidity world-wide. Therefore, effective delivery and targeting of drug to the …
mortality and morbidity world-wide. Therefore, effective delivery and targeting of drug to the …
Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: in vitro intracellular activity and in vivo efficacy in a Guinea pig model of tuberculosis
Considering that Mycobacterium tuberculosis (Mtb) can survive in host phagocytes for
decades and currently applied drugs are largely ineffective in killing intracellular Mtb, novel …
decades and currently applied drugs are largely ineffective in killing intracellular Mtb, novel …
Development and characterization of ligand-appended liposomes for multiple drug therapy for pulmonary tuberculosis
Tuberculosis (TB) remains one of the oldest and deadliest diseases in the current scenario.
The intracellular organism Mycobacterium tuberculosis, which mainly resides in …
The intracellular organism Mycobacterium tuberculosis, which mainly resides in …
Targeted intracellular delivery of antitubercular bioactive (s) to Mtb infected macrophages via transferrin functionalized nanoliposomes
The packaging of antimicrobials/chemotherapeutics into nanoliposomes can enhance their
activity while minimizing toxicity. However, their use is still limited owing to …
activity while minimizing toxicity. However, their use is still limited owing to …
Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis
CM Ribeiro, CA Roque-Borda, MC Franzini… - International Journal of …, 2024 - Elsevier
Tuberculosis (TB) is an infectious disease that annually affects millions of people, and
resistance to available antibiotics has exacerbated this situation. Another notable …
resistance to available antibiotics has exacerbated this situation. Another notable …