Conjugation of isoniazid to a zinc phthalocyanine via hydrazone linkage for pH-dependent liposomal controlled release

CI Nkanga, RWM Krause - Applied Nanoscience, 2018 - Springer
Tuberculosis (TB) remains the leading cause of mortality from infectious diseases. Extended
TB treatment and frequent adverse effects, due to poor bioavailability of anti-tubercular …

[HTML][HTML] Encapsulation of isoniazid-conjugated phthalocyanine-in-cyclodextrin-in-liposomes using heating method

CI Nkanga, RWM Krause - Scientific reports, 2019 - nature.com
Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-
tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis …

pH-Dependent release of isoniazid from isonicotinic acid (4-hydroxy-benzylidene)-hydrazide loaded liposomes

CI Nkanga, RB Walker, RW Krause - Journal of Drug Delivery Science and …, 2018 - Elsevier
Liposomes are considered as potential vehicles for the delivery of anti-tuberculosis drugs
(ATBD) due to their rapid uptake by alveolar macrophages, where the mycobacterium often …

Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate

É Kiss, D Schnöller, K Pribranska, K Hill… - Journal of dispersion …, 2011 - Taylor & Francis
Isoniazid (INH) is a first line drug for treatment of the widespread deadly disease caused by
Mycobacterium tuberculosis. Peptide conjugate of INH was designed and synthesised for …

Co-loading of isoniazid-grafted phthalocyanine-in-cyclodextrin and rifampicin in crude soybean lecithin liposomes: Formulation, spectroscopic and biological …

CI Nkanga, M Roth, RB Walker… - Journal of …, 2020 - ingentaconnect.com
An inclusion complex of isoniazid-grafted phthalocyanine with gamma-cyclodextrin
(Complex) was co-encapsulated with rifampicin (RIF) in crude soybean lecithin liposomes …

Pulmonary delivery of anti-tubercular drugs using ligand anchored pH sensitive liposomes for the treatment of pulmonary tuberculosis

A Bhardwaj, A Grobler, G Rath… - Current drug …, 2016 - ingentaconnect.com
Background: Mycobacterium tuberculosis (M. TB) remains the prime cause of bacterial
mortality and morbidity world-wide. Therefore, effective delivery and targeting of drug to the …

Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: in vitro intracellular activity and in vivo efficacy in a Guinea pig model of tuberculosis

K Horvati, B Bacsa, É Kiss, G Gyulai, K Fodor… - Bioconjugate …, 2014 - ACS Publications
Considering that Mycobacterium tuberculosis (Mtb) can survive in host phagocytes for
decades and currently applied drugs are largely ineffective in killing intracellular Mtb, novel …

Development and characterization of ligand-appended liposomes for multiple drug therapy for pulmonary tuberculosis

A Bhardwaj, L Kumar, RK Narang… - Artificial cells …, 2013 - Taylor & Francis
Tuberculosis (TB) remains one of the oldest and deadliest diseases in the current scenario.
The intracellular organism Mycobacterium tuberculosis, which mainly resides in …

Targeted intracellular delivery of antitubercular bioactive (s) to Mtb infected macrophages via transferrin functionalized nanoliposomes

P Shrivastava, A Mahale, OP Kulkarni… - International Journal of …, 2023 - Elsevier
The packaging of antimicrobials/chemotherapeutics into nanoliposomes can enhance their
activity while minimizing toxicity. However, their use is still limited owing to …

Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis

CM Ribeiro, CA Roque-Borda, MC Franzini… - International Journal of …, 2024 - Elsevier
Tuberculosis (TB) is an infectious disease that annually affects millions of people, and
resistance to available antibiotics has exacerbated this situation. Another notable …