Pathophysiological effects of contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome

J Parker - Life, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary
mismatch disorder that presents with a complex mixture of metabolic and endocrine …

Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment

J Parker, C O'brien, J Hawrelak, FL Gersh - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

Evolutionary and genetic antecedents to the pathogenesis of polycystic ovary syndrome (PCOS)

J Parker, C O'Brien - Journal of the Australasian College of …, 2021 - search.informit.org
Polycystic Ovary Syndrome is a clinical condition that effects millions of women worldwide.
The pathophysiology of PCOS involves a series of reciprocal feedback mechanisms …

Understanding the pathogenesis of polycystic ovary syndrome: transgenerational evolutionary adaptation to lifestyle and the environment

J Parker - Journal of the Australasian College of Nutritional and …, 2020 - search.informit.org
Researchers and clinicians have been trying to understand the complex interaction between
genetic and environmental factors involved in the pathogenesis of polycystic ovary …

[HTML][HTML] Evolutionary determinants of polycystic ovary syndrome: part 1

U Ünlütürk, E Sezgin, BO Yildiz - Fertility and sterility, 2016 - Elsevier
Polycystic ovary syndrome (PCOS) is a common and complex genetic disorder that
develops under varying degrees of hyperandrogenemic and hyperinsulinemic conditions …

Evolutionary origins of polycystic ovary syndrome: an environmental mismatch disorder

MA Charifson, BC Trumble - Evolution, Medicine, and Public …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and has
important evolutionary implications for female reproduction and health. PCOS presents an …

Developmental origins and transgenerational inheritance of polycystic ovary syndrome

J Parker, C O'Brien, FL Gersh - Australian and New Zealand …, 2021 - Wiley Online Library
Background There has been increasing awareness that polycystic ovary syndrome (PCOS)
phenotypes may represent a mismatch between ancient genetically programmed metabolic …

[HTML][HTML] Evolutionary determinants of polycystic ovary syndrome: part 2

DMT Fessler, B Natterson-Horowitz, R Azziz - Fertility and sterility, 2016 - Elsevier
Polycystic ovary syndrome (PCOS) is a prehistoric complex genetic trait, perhaps dating
back at least 50,000 years. The disorder also represents an evolutionary paradox …

Polycystic ovary syndrome: challenges and possible solutions

Y Che, J Yu, YS Li, YC Zhu, T Tao - Journal of Clinical Medicine, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
women of reproductive age. This syndrome not only impairs female fertility but also …

Genetic and environmental factors in the etiology of polycystic ovary syndrome

TM Barber, S Franks - The Ovary, 2019 - Elsevier
Polycystic ovary syndrome (PCOS) is a genetic condition, with phenotypic expression often
manifest through exposure to environmental factors. Recent genome-wide association …