SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes host proteases,
including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to …

The COVID-19 pandemic remains a global health threat and novel antiviral strategies are
urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into …

Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits
viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies …

As with all new virus diseases with no drug therapy, identifying key pharmacological targets
for SARS-coronavirus 2 (SARS-CoV-2 or 2019-nCoV) based on our knowledge of the viral …

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in
China and its rapid national and international spread pose a global health emergency. Cell …

The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein,
S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin …

Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic
human coronaviruses such as severe acute respiratory syndrome-related coronavirus …

Background: Host proteases have been suggested to be crucial for dissemination of MERS,
SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane …