Clinicopathological and molecular correlations in traditional serrated adenoma

S Sekine, S Yamashita, M Yamada… - Journal of …, 2020 - Springer
Background Traditional serrated adenoma (TSA) is the least common type of colorectal
serrated polyp, which exhibits considerable morphological and molecular diversity. Methods …

Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis

AJ McCarthy, S Serra, R Chetty - BMJ open …, 2019 - bmjopengastro.bmj.com
Objective To provide an overview of the pathology and molecular pathogenesis of traditional
serrated adenomas (TSA). Design Describe the morphology and molecules that play a role …

Traditional serrated adenoma has two distinct genetic pathways for molecular tumorigenesis with potential neoplastic progression

Y Tanaka, M Eizuka, N Uesugi, K Kawasaki… - Journal of …, 2020 - Springer
Background Recent studies have shown that traditional serrated adenoma (TSA) can be
classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological and …

[HTML][HTML] Molecular biomarkers of sessile serrated adenoma/polyps

P Kanth, KE Boylan, MP Bronner… - Clinical and …, 2019 - journals.lww.com
OBJECTIVES: Sessile serrated adenoma/polyps (SSA/Ps) contribute up to 30% of all colon
cancers. There is considerable histological overlap between SSA/Ps and hyperplastic …

Frequent PTPRK–RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma

S Sekine, S Yamashita, T Tanabe… - The Journal of …, 2016 - Wiley Online Library
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis,
particularly those related to traditional serrated adenomas (TSAs), are still poorly …

Acquisition of WNT pathway gene alterations coincides with the transition from precursor polyps to traditional serrated adenomas

T Hashimoto, R Ogawa, H Yoshida… - The American journal …, 2019 - journals.lww.com
Colorectal traditional serrated adenomas (TSAs) are often associated with precursor polyps,
including hyperplastic polyps and sessile serrated adenoma/polyps. To elucidate the …

[HTML][HTML] Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion

T Hashimoto, Y Tanaka, R Ogawa, T Mori, H Yoshida… - Modern Pathology, 2018 - Elsevier
We describe a series of colorectal polyps characterized by mixed adenomatous and
serrated features, herein referred to as superficially serrated adenomas. Twenty superficially …

[HTML][HTML] A clinicopathological and molecular analysis of 200 traditional serrated adenomas

ML Bettington, NI Walker, C Rosty, IS Brown… - Modern pathology, 2015 - Elsevier
The traditional serrated adenoma is the least common colorectal serrated polyp. The
clinicopathological features and molecular drivers of these polyps require further …

Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon

B Fu, S Yachida, R Morgan, Y Zhong… - American journal of …, 2012 - academic.oup.com
Traditional serrated adenomas (TSAs) are a type of colorectal polyp with neoplastic
potential. Immunohistochemical analysis and sequencing were performed on 24 TSAs from …

Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population

Y Qiu, X Fu, W Zhang, Y Xu, L Xiao, X Chen… - Journal of clinical …, 2014 - jcp.bmj.com
Aims The incidence and mortality rates from right-sided colorectal cancers (CRCs) have not
decreased in recent years. It is very likely that a significant proportion of these cancers …