A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery
In prokaryotes, translation can occur on mRNA that is being transcribed in a process called
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest
F Stevenson-Jones, J Woodgate… - Proceedings of the …, 2020 - National Acad Sciences
In bacteria, the first two steps of gene expression—transcription and translation—are
spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through …
spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through …
A translational riboswitch coordinates nascent transcription–translation coupling
Bacterial messenger RNA (mRNA) synthesis by RNA polymerase (RNAP) and first-round
translation by the ribosome are often coupled to regulate gene expression, yet how coupling …
translation by the ribosome are often coupled to regulate gene expression, yet how coupling …
Structural basis of transcription-translation coupling and collision in bacteria
MW Webster, M Takacs, C Zhu, V Vidmar, A Eduljee… - Science, 2020 - science.org
Prokaryotic messenger RNAs (mRNAs) are translated as they are transcribed. The lead
ribosome potentially contacts RNA polymerase (RNAP) and forms a supramolecular …
ribosome potentially contacts RNA polymerase (RNAP) and forms a supramolecular …
Structure-based mechanisms of a molecular RNA polymerase/chaperone machine required for ribosome biosynthesis
Bacterial ribosomal RNAs are synthesized by a dedicated, conserved transcription-
elongation complex that transcribes at high rates, shields RNA polymerase from premature …
elongation complex that transcribes at high rates, shields RNA polymerase from premature …
Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites
A Espah Borujeni, AS Channarasappa… - Nucleic acids …, 2014 - academic.oup.com
The ribosome's interactions with mRNA govern its translation rate and the effects of post-
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
[HTML][HTML] The RNA–DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase
E Nudler, A Mustaev, A Goldfarb, E Lukhtanov - Cell, 1997 - cell.com
Abstract An 8–9 bp RNA–DNA hybrid in the transcription elongation complex is essential for
keeping the RNA 3′ terminus engaged with the active site of E. coli RNA polymerase …
keeping the RNA 3′ terminus engaged with the active site of E. coli RNA polymerase …
Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand
A Chauvier, JC Porta, I Deb, E Ellinger… - Nature Structural & …, 2023 - nature.com
Folding of nascent transcripts can be modulated by the RNA polymerase (RNAP) that carries
out their transcription, and vice versa. A pause of RNAP during transcription of a preQ1 …
out their transcription, and vice versa. A pause of RNAP during transcription of a preQ1 …
[HTML][HTML] Linking RNA polymerase backtracking to genome instability in E. coli
D Dutta, K Shatalin, V Epshtein, ME Gottesman… - Cell, 2011 - cell.com
Frequent codirectional collisions between the replisome and RNA polymerase (RNAP) are
inevitable because the rate of replication is much faster than that of transcription. Here we …
inevitable because the rate of replication is much faster than that of transcription. Here we …
Disruption of transcription–translation coordination in Escherichia coli leads to premature transcriptional termination
Tight coordination between transcription and translation is crucial to maintaining the integrity
of gene expression in bacteria, yet how bacteria manage to coordinate these two processes …
of gene expression in bacteria, yet how bacteria manage to coordinate these two processes …