Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific
target genes have yet been identified. Here, we describe the finding of homozygous EZH2 …

In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and
correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We …

B cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2
histone methyltransferase (EZH2), but the carcinogenic role of these mutations is unclear …

EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …

Recent evidence shows increased and decreased expression of Ezh2 in cancer, suggesting
a dual role as an oncogene or tumour suppressor. To investigate the mechanism by which …

Chromatin is organized into topologically associating domains (TADs) enriched in distinct
histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of …

3 Horton JK, Prasad R, Hou E, Wilson SH. Protection against methylation-induced
cytotoxicity by DNA polymerase b-dependent long patch base excision repair. J Biol Chem …

Our understanding of the significance of epigenetic dysregulation in the pathogenesis of
myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog …

Control of gene expression is exerted at a number of different levels, one of which is the
accessibility of genes and their controlling elements to the transcriptional machinery …

Abstract Polycomb repressive complex 2 (PRC2) is involved in trimethylation of histone H3
lysine 27 (H3K27), chromatin condensation and transcriptional repression. The silencing …