Furosemide is the diuretic most used in newborn infants. It blocks the Na+-K+-2Cl−
symporter in the thick ascending limb of the loop of Henle increasing urinary excretion of …

Objective: To evaluate the effect of furosemide on renal function and water balance in
preterm infants treated with indomethacin (3× 0.2 mg/kg at 12‐h intervals) for symptomatic …

• Furosemide is a known stimulant of the renal release of prostaglandin E 2, a potent dilator
of the ductus arteriosus. A possible relationship between furosemide use in infants with …

The pharmacokinetics of furosemide were studied longitudinally during long-term
administration in 10 very low birth weight infants with bronchopulmonary dysplasia. Mean …

The loop diuretics furosemide and bumetanide are used widely for the management of fluid
overload in both acute and chronic disease states. To date, most pharmacokinetic studies in …

Using a one-compartment model, the pharmacokinetic disposition offurosemide was studied
in eight premature and term neonates with fluid overload. Following a single intravenous …

Objective To evaluate the association between furosemide exposure and patent ductus
arteriosus (PDA) in a large, contemporary cohort of hospitalized infants with very low birth …

The effects of furosemide on electrolyte and water excretion were determined in 9 neonates
with fluid overload states. Hourly measurements of urine volume, serum and urine Na+, K+ …

To determine whether long-term renal sequelae follow the use of furosemide in preterm
infants, we evaluated renal function in 27 former very low birth weight infants (< 1500 gm) at …

Furosemide is a commonly used loop diuretic in neonatal intensive care. The common
indications for the use of diuretics in neonates are fluid retention with adequate circulating …