Divergence of cis-regulatory elements drives species-specific traits, but how this manifests in
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

Although genome sequencing has identified numerous noncoding alterations between
primate species, which of those are regulatory and potentially relevant to the evolution of the …

Neuroanatomically precise, genome-wide maps of transcript distributions are critical
resources to complement genomic sequence data and to correlate functional and genetic …

Proper assembly and function of the nervous system requires the generation of a uniquely
diverse population of neurons expressing a cell-type-specific combination of effector genes …

The transcriptional underpinnings of brain development remain poorly understood,
particularly in humans and closely related non-human primates. We describe a high …

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

Mammalian tissues are composed of highly specialized cell types defined by distinct gene
expression patterns. Identification of cis-regulatory elements responsible for cell-type …

Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …