For nearly 30 years, the endogenous bioactivity of insulin-like growth factor I (IGF-I) has
been estimated by its circulating concentrations of immunoreactive IGF-I, obtained after …

Free IGF-I by analogy with sex and adrenal steroids and thyroid hormones, may be the
major biologically active hormonal form of IGF-I. Because of methodological difficulties in …

Most circulating IGF-I (about 99%) is bound to insulin-like growth factor binding proteins
(IGFBPs), while a very small component (0.5-1%) circulates as a free (= unbound) form (1) …

Context: GH is considered the main regulator of circulating IGF-I. Total (extractable) IGF-I is
therefore routinely used for diagnosis of GH deficiency (GHD) and for monitoring treatment …

Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth
hormone (GH) status. As a large number of determinants including age, gender, genetic …

OBJECTIVE Insulin‐like growth factor I (IGF‐I) and IGF binding protein‐3 (IGFBP‐3) are GH‐
dependent and their concentrations have been used in the diagnosis of GH deficiency …

For almost three decades, the measurement of circulating IGF-I has constituted a highly
important biochemical tool in the management of GH disorders. In fact, in acromegaly the …

At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by
immunological measurements of IGF-I levels. However, immunoassays ignore the modifying …

The objective of the present study was to compare fasting levels of free IGF-I in serum from
patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and …

Serum insulin-like growth factor I (IGF-I) levels predominantly reflect the hepatic effect of
growth hormone (GH). Compared with serum GH levels, which reflect pulsatile GH secretion …