The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably
impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases …

Exosomes, nanoscale extracellular vesicles functioning as cell-to-cell communicators, are
an emerging promising therapeutic in the field of bone tissue engineering. Here, we report …

Repair of large bone defects represents a major challenge for orthopedic surgeons. The
newly formed microvessels inside grafts play a crucial role in successful bone tissue …

In-situ bone tissue regeneration, which harnesses cell external microenvironment and their
regenerative potential to induce cell functions and bone reconstruction through some …

The treatment of bone defects has plagued clinicians. Exosomes, the naturally secreted
nanovesicles by cells, exhibit great potential in bone defect regeneration to realize cell-free …

Bone marrow mesenchymal stromal cell-derived exosomes (BMSC-Exos) can recruit stem
cells for bone repair, with neovessels serving as the main migratory channel for stem cells to …

Large segmental bone regeneration remains a great challenge due to the lack of
vascularization in newly formed bone. Conventional strategies primarily combine bone …

Chronic diabetic wound injury is a serious syndrome of diabetes, and the treatment of this
syndrome is of great significance. Owing to metabolic abnormalities, diabetic wounds are …

Exosomes derived from mesenchymal stem cells (MSCs) have demonstrated regenerative
potential for cell-free bone tissue engineering, nevertheless, certain challenges, including …

As an emerging cell-free therapy, exosomes derived from stem cells have been widely
explored for tissue regeneration. However, it is still a great challenge to achieve the …