Background GBP s (guanylate binding proteins), an evolutionary ancient protein family, play
a key role in the host's innate immune response against bacterial, parasitic and viral …

Guanylate binding proteins (GBPs) are major players in the host immunity, providing
defense against bacterial and viral invaders. Multigene families may suffer different …

Guanylate binding proteins (GBPs) are paramount in the host immunity by providing defense
against invading pathogens. Multigene families related to the immune system usually show …

Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely
distributed among eukaryotes. They are interferon (IFN)-inducible guanosine …

Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are
widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases …

The interactions between pathogens and hosts lead to a massive upregulation of
antimicrobial host effector molecules. Among these, the 65 kDa guanylate binding proteins …

Following viral detection and interferons (IFNs) production, several hundreds of IFN-
stimulated genes (ISGs) are subsequently induced to act as direct antiviral effectors or …

Innate immunity is the first line of host defense against viral infection. After invading into the
cells, pathogen-associated-molecular-patterns derived from viruses are recognized by …

Being permanently exposed to pathogens and infectious agents, vertebrates evolved
several mechanisms to protect against. They are primarily equipped with physical and …

Guanylate-binding proteins (GBPs) are immune GTPases that are induced in response to
interferon stimulation/pathogen infection. These proteins arose early in evolution and have …