IMPLICATIONS: Acute respiratory failure is characterized by severe decreases in blood
oxygen. The pattern of blood flow within the lungs can contribute to this problem. This study …

Background Mechanical ventilation using tidal volumes around 10 ml/kg and zero positive
end-expiratory pressure is still commonly used in anesthesia. This strategy has been shown …

Background Alveolar overdistension and repetitive derecruitment-recruitment contribute to
ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell …

Respiratory support with mechanical ventilation is crucial for critically ill patients with
diseases such as acute respiratory distress syndrome (ARDS), in which the pulmonary gas …

Background Atelectasis results in impaired compliance and gas exchange and, in extreme
cases, increased microvascular permeability, pulmonary hypertension, and right ventricular …

Background The concept of antiinflammatory effects of volatile anesthetics is well
established in vitro and in some organ systems. Their protective role in lung injury, however …

Background There is limited information on the regional inflammatory effects of mechanical
ventilation and endotoxemia on the production of acute lung injury. Measurement of F …

Editorial Views animals with DNase in order to degrade NeTs, they observed no significant
impact on lung injury in their model. The detection of NeTs, especially in vivo, remains …

Acute lung injury (ALI) or its severe form, acute respiratory distress syndrome (ARDS), is one
of the common causes of acute respiratory failure. Although critical care management has …

Background Endotoxin causes acute lung injury, which can lead to acute respiratory distress
syndrome. Because local anesthetics are known to attenuate inflammatory reactions …