Genome-wide association studies have identified common variants that only partially
explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from …

Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta …

The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule. IRS-2
inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance …

We examined the gene and protein expression of IRS 1 (insulin receptor substrate 1) in
adipocytes from two groups of healthy individuals with an increased propensity for non …

The insulin receptor substrate (IRS)-1 is an important component of the insulin signal
transduction cascade. Several reports suggest that a Gly→ Arg change in codon 972 is …

Aims/hypothesis Several case-control studies have examined the association between the
Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and …

Type 2 diabetes is a complex disease characterized by insulin resistance in target tissues
and a reduced capacity to produce compensatory levels of insulin in pancreatic-cells (1). Not …

Genome-wide association studies are now identifying disease-associated chromosome
regions. However, even after convincing replication, the localization of the causal variant (s) …

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …