Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques
causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived …

Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

Astrocytes control tissue equilibrium and hence define the homoeostasis and function of the
CNS (central nervous system). Being principal homoeostatic cells, astroglia are fundamental …

Since it was first generally accepted that the two amino acids glutamate and GABA act as
principal neurotransmitters, several landmark discoveries relating to this function have been …

Astrocytes become activated in Alzheimer's disease (AD), contributing to and reinforcing an
inflammatory cascade. It is proposed that by transforming from a basal to a reactive state …

Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Astrocytes are fundamental for brain homeostasis and the progression and outcome of many
neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model …

Metabolism of glutamate, the main excitatory neurotransmitter and precursor of GABA, is
exceedingly complex and highly compartmentalized in brain. Maintenance of these …

The conventional view of central nervous system (CNS) metabolism is based on the
assumption that glucose is the main fuel source for active neurons and is processed in an …