Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

DN Tippett, C Breen, SJ Butler, M Sawicka, R Dutzler - Elife, 2023 - elifesciences.org
Members of the SLC26 family constitute a conserved class of anion transport proteins, which
encompasses uncoupled transporters with channel-like properties, coupled exchangers and …

SLC26 anion transporters

ER Geertsma, D Oliver - Anion Channels and Transporters, 2023 - Springer
Abstract Solute carrier family 26 (SLC26) is a family of functionally diverse anion
transporters found in all kingdoms of life. Anions transported by SLC26 proteins include …

Identification of multiple substrate binding sites in SLC4 transporters in the outward-facing conformation: Insights into the transport mechanism

HR Zhekova, A Pushkin, G Kayık, L Kao… - Journal of Biological …, 2021 - ASBMB
Solute carrier family 4 (SLC4) transporters mediate the transmembrane transport of HCO 3−,
CO 3 2−, and Cl− necessary for pH regulation, transepithelial H+/base transport, and ion …

Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters

E Ohana, N Shcheynikov, D Yang, I So… - Journal of General …, 2011 - rupress.org
Members of the SLC26 family of anion transporters mediate the transport of diverse
molecules ranging from halides to carboxylic acids and can function as coupled transporters …

[HTML][HTML] SLC26 Cl-/HCO3-exchangers in the kidney: roles in health and disease

M Soleimani - Kidney international, 2013 - Elsevier
Solute-linked carrier 26 (SLC26) isoforms constitute a conserved family of anion transporters
with 10 distinct members. Except for SLC26A5 (prestin), all can operate as multifunctional …

NBCe1 as a model carrier for understanding the structure–function properties of Na+-coupled SLC4 transporters in health and disease

I Kurtz - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
SLC4 transporters are membrane proteins that in general mediate the coupled transport of
bicarbonate (carbonate) and share amino acid sequence homology. These proteins differ as …

[HTML][HTML] The role of SLC26A6-mediated chloride/oxalate exchange in causing susceptibility to nephrolithiasis

M Soleimani - The Journal of Physiology, 2008 - ncbi.nlm.nih.gov
Solute-linked carrier 26 (SLC26) isoforms are members of a large, conserved family of anion
exchangers, which encompasses at least 10 distinct genes or isoforms (SLC26A1–11)(Kere …

Slc26a9—Anion Exchanger, Channel and Na+ Transporter

MH Chang, C Plata, K Zandi-Nejad, A Sinđić… - Journal of membrane …, 2009 - Springer
The SLC26 gene family encodes anion transporters with diverse functional attributes:(a)
anion exchanger,(b) anion sensor, and (c) anion conductance (likely channel). We have …

Expression, Regulation and the Role of SLC26 Cl/HCO3 Exchangers in Kidney and Gastrointestinal Tract

M Soleimani - Epithelial Anion Transport in Health and Disease …, 2006 - Wiley Online Library
SLC26 isoforms are members of a large, conserved family of anion exchangers that display
highly restricted and distinct tissue distribution. Cloning experiments have identified the …

[HTML][HTML] A molecular analysis of the Na+-independent cation chloride cotransporters

KB Gagnon, M Di Fulvio - Cellular Physiology and Biochemistry, 2013 - karger.com
The homologous genes encoding the electroneutral solute carrier family 12A (SLC12A)
were identified more than 20 years ago, however, over the last few years, it has become …