[HTML][HTML] The roles of metallothioneins in carcinogenesis

M Si, J Lang - Journal of hematology & oncology, 2018 - Springer
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Metallothionein isoforms as double agents–their roles in carcinogenesis, cancer progression and chemoresistance

MAM Rodrigo, AMJ Jimemez, Y Haddad… - Drug Resistance …, 2020 - Elsevier
Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms
identified in mammals, designated MT-1 through MT-4. The best known biological functions …

Metallothionein: a multifunctional protein from toxicity to cancer

SE Theocharis, AP Margeli… - … International journal of …, 2003 - journals.sagepub.com
The metallothionein (MT) family is a class of low molecular weight, intracellular and cysteine-
rich proteins presenting high affinity for metal ions. Although the members of this family were …

Metallothioneins in human tumors and potential roles in carcinogenesis

MG Cherian, A Jayasurya, BH Bay - Mutation Research/Fundamental and …, 2003 - Elsevier
Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular
proteins, which are encoded by a family of genes containing at least 10 functional isoforms …

Metallothionein 2A expression is associated with cell proliferation in breast cancer

R Jin, VTK Chow, PH Tan, ST Dheen, W Duan… - …, 2002 - academic.oup.com
Metallothioneins (MTs) belong to a family of cysteine-rich, metal-binding intracellular
proteins, which have been linked with cell proliferation. In this study, expression levels of the …

Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas

J Mao, H Yu, C Wang, L Sun, W Jiang, P Zhang… - …, 2012 - academic.oup.com
Members of the metallothionein (MT) family are short, cysteine-rich proteins involved in
metal metabolism and detoxification, suggesting that MT proteins protect cells from damage …

Metallothioneins and cancer

T Eckschlager, V Adam, J Hrabeta… - Current Protein and …, 2009 - ingentaconnect.com
Metallothioneins (MTs) are low molecular, cysteine-rich proteins that have naturally-
occurring Zn2+ in both clusters. They may serve as a reservoir of metals for synthesis of …

[HTML][HTML] Molecular functions of metallothionein and its role in hematological malignancies

S Takahashi - Journal of hematology & oncology, 2012 - Springer
Metallothionein (MT) was reported to be a potential negative regulator of apoptosis, and
various reports have suggested that it may play roles in carcinogenesis and drug resistance …

The role of metallothionein in oncogenesis and cancer prognosis

MØ Pedersen, A Larsen, M Stoltenberg… - … in histochemistry and …, 2009 - Elsevier
The antiapoptotic, antioxidant, proliferative, and angiogenic effects of metallothionein (MT)-
I+ II has resulted in increased focus on their role in oncogenesis, tumor progression, therapy …

[HTML][HTML] A review of metallothionein isoforms and their role in pathophysiology

N Thirumoorthy, A Shyam Sunder… - World journal of surgical …, 2011 - Springer
The Metallothionein (MT) is a protein which has several interesting biological effects and
has been demonstrated increase focus on the role of MT in various biological systems in the …