STUDY QUESTION What clinical practices, patient management strategies and
experimental methods are currently being used to preserve and restore the fertility of …

Young boys undergoing gonadotoxic treatments are at high risk of spermatogonial stem cell
(SSC) loss and fertility problems later in life. Stem cell loss can also occur in specific genetic …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or
genetic predisposition can occur at any age. Although semen cryopreservation is the first …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …

BACKGROUND Banking of testicular tissue from pre-pubertal boys before gonadotoxic
treatment is a crucial step in fertility preservation. We wanted to find optimal methods for …

BACKGROUND Since prepubertal boys cannot benefit from sperm banking, a potential
alternative strategy for fertility preservation involves immature testicular tissue (ITT) banking …

BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Cryopreservation of testicular tissue might benefit prepubertal boys who must undergo
chemotherapy or radiotherapy. Cryopreservation of testicular tissue and testicular cells for …

BACKGROUND: Cryopreservation of testicular tissue is an option in fertility preservation for
pre-pubertal boys who will lose spermatogenic cells as a result of chemotherapy. We …