Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

CM Rudin, JT Poirier, LA Byers, C Dive… - Nature Reviews …, 2019 - nature.com
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …

Targeted therapies and biomarkers in small cell lung cancer

H Taniguchi, T Sen, CM Rudin - Frontiers in oncology, 2020 - frontiersin.org
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid growth,
early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have …

[HTML][HTML] Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies

J Ng, L Cai, L Girard, OWJ Prall, N Rajan, C Khoo… - Clinical Cancer …, 2024 - AACR
Purpose: The classification of small cell lung cancer (SCLC) into distinct molecular subtypes
defined by ASCL1, NEUROD1, POU2F3, or YAP1 (SCLC-A,-N,-P, or-Y) expression, paves …

Small cell lung cancer: Subtypes and therapeutic implications

WZ Wang, A Shulman, JM Amann, DP Carbone… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …

Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study

Z Megyesfalvi, N Barany, A Lantos… - The Journal of …, 2022 - Wiley Online Library
The tissue distribution and prognostic relevance of subtype‐specific proteins (ASCL1,
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …

[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate

AS Ireland, AM Micinski, DW Kastner, B Guo, SJ Wait… - Cancer cell, 2020 - cell.com
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …

[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

JM Chan, A Quintanal-Villalonga, VR Gao, Y Xie… - Cancer cell, 2021 - cell.com
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …

Molecular profiles of small cell lung cancer subtypes: therapeutic implications

A Schwendenwein, Z Megyesfalvi, N Barany… - Molecular Therapy …, 2021 - cell.com
Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers)
is an exceptionally lethal malignancy characterized by rapid doubling time and high …

[HTML][HTML] Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

CM Gay, CA Stewart, EM Park, L Diao, SM Groves… - Cancer cell, 2021 - cell.com
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …

Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

D Lissa, N Takahashi, P Desai, I Manukyan… - Nature …, 2022 - nature.com
Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …