Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
therapies are urgently needed. Several lines of evidence, from SCLC primary human …
Targeted therapies and biomarkers in small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid growth,
early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have …
early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have …
[HTML][HTML] Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies
J Ng, L Cai, L Girard, OWJ Prall, N Rajan, C Khoo… - Clinical Cancer …, 2024 - AACR
Purpose: The classification of small cell lung cancer (SCLC) into distinct molecular subtypes
defined by ASCL1, NEUROD1, POU2F3, or YAP1 (SCLC-A,-N,-P, or-Y) expression, paves …
defined by ASCL1, NEUROD1, POU2F3, or YAP1 (SCLC-A,-N,-P, or-Y) expression, paves …
Small cell lung cancer: Subtypes and therapeutic implications
WZ Wang, A Shulman, JM Amann, DP Carbone… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study
Z Megyesfalvi, N Barany, A Lantos… - The Journal of …, 2022 - Wiley Online Library
The tissue distribution and prognostic relevance of subtype‐specific proteins (ASCL1,
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Molecular profiles of small cell lung cancer subtypes: therapeutic implications
A Schwendenwein, Z Megyesfalvi, N Barany… - Molecular Therapy …, 2021 - cell.com
Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers)
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
[HTML][HTML] Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
CM Gay, CA Stewart, EM Park, L Diao, SM Groves… - Cancer cell, 2021 - cell.com
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …
single entity with predictably poor results. Using tumor expression data and non-negative …
Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
D Lissa, N Takahashi, P Desai, I Manukyan… - Nature …, 2022 - nature.com
Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …
transcription regulators have recently been proposed in cell lines and limited number of …