Microglial regional heterogeneity and its role in the brain

YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …

Analyzing microglial phenotypes across neuropathologies: a practical guide

M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

Region-specific phenotypes of microglia: the role of local regulatory cues

LM De Biase, A Bonci - The Neuroscientist, 2019 - journals.sagepub.com
Microglia are ubiquitous, macrophage like cells within the central nervous system (CNS) that
play critical roles in supporting neuronal health and viability. They can also influence …

A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease

A Patir, B Shih, BW McColl, TC Freeman - Glia, 2019 - Wiley Online Library
Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …

[PDF][PDF] Microglia heterogeneity in the single-cell era

T Masuda, R Sankowski, O Staszewski, M Prinz - Cell reports, 2020 - cell.com
Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

[HTML][HTML] Microglia in health and disease: the strength to be diverse and reactive

O Uriarte Huarte, L Richart, M Mittelbronn… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …

Mapping microglia states in the human brain through the integration of high-dimensional techniques

R Sankowski, C Böttcher, T Masuda, L Geirsdottir… - Nature …, 2019 - nature.com
Microglia are tissue-resident macrophages of the CNS that orchestrate local immune
responses and contribute to several neurological and psychiatric diseases. Little is known …

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

PD Wes, IR Holtman, EWGM Boddeke, T Möller… - Glia, 2016 - Wiley Online Library
Genome‐wide expression profiling technology has resulted in detailed transcriptome data
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …

White matter microglia heterogeneity in the CNS

S Amor, NB McNamara, E Gerrits, MC Marzin… - Acta …, 2022 - Springer
Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in
shaping the brain during development, responding to invading pathogens, and clearing …

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

C Sousa, A Golebiewska, SK Poovathingal… - EMBO …, 2018 - embopress.org
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …