Microglial regional heterogeneity and its role in the brain
YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …
heterogeneity across different regions in the mammalian central nervous system (CNS) …
Analyzing microglial phenotypes across neuropathologies: a practical guide
M Schwabenland, W Brück, J Priller, C Stadelmann… - Acta …, 2021 - Springer
As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …
Region-specific phenotypes of microglia: the role of local regulatory cues
LM De Biase, A Bonci - The Neuroscientist, 2019 - journals.sagepub.com
Microglia are ubiquitous, macrophage like cells within the central nervous system (CNS) that
play critical roles in supporting neuronal health and viability. They can also influence …
play critical roles in supporting neuronal health and viability. They can also influence …
A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's disease
Growing recognition of the pivotal role microglia play in neurodegenerative and
neuroinflammatory disorders has accentuated the need to characterize their function in …
neuroinflammatory disorders has accentuated the need to characterize their function in …
[PDF][PDF] Microglia heterogeneity in the single-cell era
Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …
carrying out prominent and various functions during development and adulthood under both …
[HTML][HTML] Microglia in health and disease: the strength to be diverse and reactive
O Uriarte Huarte, L Richart, M Mittelbronn… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …
reacting to any perturbation in order to maintain CNS homeostasis. Although their …
Mapping microglia states in the human brain through the integration of high-dimensional techniques
R Sankowski, C Böttcher, T Masuda, L Geirsdottir… - Nature …, 2019 - nature.com
Microglia are tissue-resident macrophages of the CNS that orchestrate local immune
responses and contribute to several neurological and psychiatric diseases. Little is known …
responses and contribute to several neurological and psychiatric diseases. Little is known …
Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
Genome‐wide expression profiling technology has resulted in detailed transcriptome data
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
for a wide range of tissues, conditions and diseases. In neuroscience, expression datasets …
White matter microglia heterogeneity in the CNS
S Amor, NB McNamara, E Gerrits, MC Marzin… - Acta …, 2022 - Springer
Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in
shaping the brain during development, responding to invading pathogens, and clearing …
shaping the brain during development, responding to invading pathogens, and clearing …
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …