Carcinogenicity of chromium and chemoprevention: a brief update

Y Wang, H Su, Y Gu, X Song, J Zhao - OncoTargets and therapy, 2017 - Taylor & Francis
Chromium has two main valence states: hexavalent chromium (Cr [VI]) and trivalent
chromium (Cr [III]). Cr (VI), a well-established human carcinogen, can enter cells by way of a …

Chromium genotoxicity: A double-edged sword

KP Nickens, SR Patierno, S Ceryak - Chemico-biological interactions, 2010 - Elsevier
Certain forms of hexavalent chromium [Cr (VI)] are known respiratory carcinogens that
induce a broad spectrum of DNA damage. Cr (VI)-carcinogenesis may be initiated or …

Mechanisms of chromium-induced toxicity

TL DesMarias, M Costa - Current opinion in toxicology, 2019 - Elsevier
Chromium is a pervasive environmental contaminant that is of great importance because of
its toxicity. Hexavalent chromium is a classified group 1 carcinogen with multiple complex …

Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis

J Singh, DL Carlisle, DE Pritchard… - Oncology …, 1998 - spandidos-publications.com
The adverse health effects linked with chromium (Cr) exposure, the role of solubility and
chemical speciation of Cr compounds, and the diverse cellular and molecular effects of Cr …

Mechanisms and individuality in chromium toxicity in humans

T Pavesi, JC Moreira - Journal of Applied Toxicology, 2020 - Wiley Online Library
With regards to health, chromium (Cr) is an ambiguous chemical element. Although it is
considered to be an important micronutrient, it also is connected with several pathologies …

Threshold mechanisms and site specificity in chromium (VI) carcinogenesis

S De Flora - Carcinogenesis, 2000 - academic.oup.com
Ten years have elapsed since the International Agency for Research on Cancer (IARC)
evaluated the carcinogenicity of chromium and chromium compounds. Further studies …

Mechanisms of chromium carcinogenicity and toxicity

MD Cohen, B Kargacin, CB Klein… - Critical reviews in …, 1993 - Taylor & Francis
Chromium, like many transition metal elements, is essential to life at low concentrations yet
toxic to many systems at higher concentrations. In addition to the overt symptoms of acute …

Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms

TJ O'Brien, S Ceryak, SR Patierno - Mutation Research/Fundamental and …, 2003 - Elsevier
Certain hexavalent chromium (Cr (VI))-containing compounds are recognized occupational
human lung carcinogens and may pose an environmental health risk. The carcinogenicity of …

Molecular basis of hexavalent chromium carcinogenicity: effect on gene expression

KE Wetterhahn, JW Hamilton - Science of the total environment, 1989 - Elsevier
The carcinogenicity of chromium (VI) compounds is explained in terms of the “uptake-
reduction” model. According to this model, chromium (VI) enters cells as the anionic …

A comprehensive review on human health effects of chromium: Insights on induced toxicity

H Hossini, B Shafie, AD Niri, M Nazari… - … Science and Pollution …, 2022 - Springer
The growing use of heavy metals in most industrial activities has led to it being considered
as the most important environmental pollutant that may cause harm and toxicity to animals …