Background Intervertebral disc (IVD) shows aging and degenerative changes earlier than
any other body connective tissue. Its repair and regeneration provide a considerable …

Objective The effect of Sox9 on the differentiation of bone marrow mesenchymal stem cells
(BMSCs) to nucleus pulposus (NP)-like (chondrocyte-like) cells in vitro has been …

BACKGROUND Intervertebral disc degeneration (IVDD) is the leading cause of lower back
pain. Disc degeneration is characterized by reduced cellularity and decreased production of …

Although Sox9 is essential for chondrogenic differentiation and matrix production, its
application in cartilage tissue engineering has been rarely reported. In this study, the …

Cartilage has a limited capacity to heal. Previously, we have shown that overexpression of
Sox11 in rMSCs (Rat Mesenchymal Stem Cells) by lentivirus-mediated gene transfer leads …

Sox9 is a transcription factor that regulates chondrogenesis, but its role in the chondrogenic
differentiation of mesenchymal stem cells (MSCs) triggered by materials is poorly …

Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors
involved in the cartilage regeneration. However, it also exhibits osteogenic abilities and …

Bone morphogenetic protein 2 (BMP2) induces effective chondrogenesis of mesenchymal
stem cells (MSCs) by promoting Sox9 expression. However, BMP2 also induces …

To investigate the regulatory effect of carbohydrate sulfotransferase 3 (CHST3) in cartilage
endplate‐derived stem cells (CESCs) on the molecular mechanism of intervertebral disc …

We investigated chondrogenesis of cell-mediated sox9 gene therapy as a new treatment
regimen for cartilage regeneration. pIRES2-EGFP vector containing a full-length mouse …