Characterization of the peripheral action of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system

R Couture, O Laneuville, C Guimond… - Naunyn-Schmiedeberg's …, 1989 - Springer
The effects on mean arterial pressure (MAP) and heart rate (HR) of increasing doses (0.65–
65 nmol/kg) of substance P (SP), neurokinin A (NKA), neurokinin B (NKB) and selective …

Spinal action of neurokinins producing cardiovascular responses in the conscious freely moving rat: evidence for a NK-1 receptor mechanism

H Hasséssian, G Drapeau, R Couture - Naunyn-Schmiedeberg's archives …, 1988 - Springer
This study was initiated to characterize the receptors which mediate the cardiovascular
responses elicited by the intrathecal (i. th.) administration of neurokinins (NK) in the …

Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors

JW Constantine, WS Lebel, HA Woody - Naunyn-Schmiedeberg's archives …, 1991 - Springer
The effects of substance P, neurokinin A, neurokinin B,[Sar 9, Met (O 2) 11]-substance P,[Nle
10] neurokinin A (4–10) and senktide {succinyl-[Asp 6, McPhe 8]-substance P (6–11)} on …

Vasoconstrictor and dilator responses to neurokinin A in isolated guinea pig heart

DB Hoover, FE Hossler - Peptides, 1993 - Elsevier
Abstract Effects of neurokinin A (NKA) and substance P (SP) on coronary resistance vessels
were studied in isolated guinea pig hearts perfused with isotonic buffer containing 20 mM …

Effect of a tachykinin NK2 receptor antagonist, nepadutant, on cardiovascular and gastrointestinal function in rats and dogs

S Giuliani, M Guelfi, M Toulouse, L Buéno… - European journal of …, 2001 - Elsevier
The effect of the tachykinin NK2 receptor antagonist, nepadutant (MEN 11420 or (c {[(β-d-
GlcNAc) Asn–Asp–Trp–Phe–Dpr–Leu] c (2β–5β)})) was assessed on cardiovascular …

Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists

P Picard, D Regoli, R Couture - British journal of pharmacology, 1994 - Wiley Online Library
1 The effects of intracerebroventricular (icv) injection of selective and potent NK1 (RP
67580), NK2 (SR 48968) and NK3 (R 486,[Trp7, β‐Ala8] NKA (4–10)) receptor antagonists …

Use of selective antagonists to dissociate the central cardiovascular and behavioural effects of tachykinins on NK1 and NK2 receptors in the rat.

C Tschöpe, P Picard, J Culmann, A Prat… - British journal of …, 1992 - ncbi.nlm.nih.gov
The effects of intracerebroventricular (icv) pretreatment with selective NK1 ((+/-)-CP 96,345),
NK2a (MEN 10,207; MEN 10,376) and NK2b (R 396) tachykinin receptor antagonists on the …

Study of SR 142801, a new potent non‐peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea‐pig

A Roccon, D Marchionni… - British journal of …, 1996 - Wiley Online Library
1 The cardiovascular responses to intravenous (iv) injection of natural tachykinins,
substance P (SP), neurokinin A (NKA), neurokinin B (NKB) and selective tachykinin (NK) …

Implication of nigral tachykinin NK3 receptors in the maintenance of hypertension in spontaneously hypertensive rats: a pharmacologic and autoradiographic study

A Lessard, MM Campos… - British journal of …, 2003 - Wiley Online Library
The role of nigral tachykinin NK1, NK2 and NK3 receptors in central cardiovascular
regulation was studied by measuring the effects of selective agonists and antagonists on …

Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress

J Culman, S Klee, C Ohlendorf, T Unger - Journal of Pharmacology and …, 1997 - ASPET
The neurokinins, substance P (SP) and neurokinin A (NKA) represent natural, nonspecific
ligands of NK1 and NK2receptors. In our study in conscious rats, we tested the hypothesis …