Induction of tolerogenicity following a molecular dialogue between HTLV-1-infected T cells and dendritic cells

H Dutartre, A Carcone, F Mortreux, S Alais, C Mathieu… - 2024 - researchsquare.com
Manipulation of immune cell functions, independently of direct infection of these cells,
emerges as a key process in viral pathophysiology. Chronic infection by Human T-cell …

Induction of tolerogenicity following a molecular dialogue between HTLV-1-infected T cells and dendritic cells

A Carcone, F Mortreux, S Alais, C Mathieu, C Journo… - bioRxiv, 2024 - biorxiv.org
Manipulation of immune cell functions, independently of direct infection of these cells,
emerges as a key process in viral pathophysiology. Chronic infection by Human T-cell …

Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice

S Rahman, SL Manuel, ZK Khan, B Wigdahl… - The Journal of …, 2010 - journals.aai.org
Human T cell leukemia virus type 1 (HTLV-1) is associated with two immunologically distinct
diseases: HTLV-1–associated myelopathy/tropical spastic paraparesis and adult T cell …

Distinct DC subsets are not equally susceptible to HTLV-1 infection

S Alais, A Glaize, A Cachat, F Lamouche, R Mahieux… - Retrovirology, 2014 - Springer
Beside lymphocytes, HTLV-1 can infect monocytes, bloodor monocytes-derived dendritic
cells (DCs) and plasmacytoïd DCs in vitro. Considering that DCs might be the first cells to be …

Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice

S Rahman, SL Manuel, ZK Khan, B Wigdahl… - Retrovirology, 2014 - Springer
HTLV-1 is associated with two immunologically distinct diseases: HTLV-1-associated
myelopathy/tropical spastic paraparesis and adult T cell leukemia. The genesis of these …

How does susceptibility to HTLV-1 infection varies with the maturation state of dendritic cells?

G Rizkallah, C Journo, R Mahieux, H Dutartre - Future Virology, 2017 - Taylor & Francis
Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma and HTLV-1-associated myelopathy. In patients, the provirus is …

The avidity and lytic efficiency of the CTL response to HTLV-1

T Kattan, A MacNamara, AG Rowan… - The Journal of …, 2009 - journals.aai.org
In human T-lymphotropic virus type 1 (HTLV-1) infection, a high frequency of HTLV-1-
specific CTLs can co-exist stably with a high proviral load and the proviral load is strongly …

[HTML][HTML] Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

M Künzli, P Reuther, DD Pinschewer, CG King - Elife, 2021 - elifesciences.org
A hallmark of adaptive immunity is CD4 T cells' ability to differentiate into specialized
effectors. A long-standing question is whether T cell receptor (TCR) signal strength can …

Murine FLT3 ligand-derived dendritic cell-mediated early immune responses are critical to controlling cell-free human T cell leukemia virus type 1 infection

S Rahman, ZK Khan, B Wigdahl, S Jennings, F Tangy… - Retrovirology, 2014 - Springer
Human T cell leukemia virus type 1 (HTLV-1) is associated with two immunologically distinct
diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T cell …

Different routes of entry of HTLV-1 during infection of primary dendritic cells and CD4+ T cells

KS Jones, C Petrow-Sadowski, DC Bertolette, N Enam… - Retrovirology, 2014 - Springer
Although HTLV-1 is primarily found in T cells in infected individuals, ex vivo cultures of T
cells are not readily infected by cell-free HTLV-1. In contrast, cell-free HTLV-1 efficiently …