Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts
Oncostatin M (OSM) belongs to IL‐6 subfamily and is mostly produced by T lymphocytes.
High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it …
High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it …
Oncostatin M decreases interleukin‐1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo
A Dumas, S Lagarde, C Laflamme… - Journal of cellular and …, 2012 - Wiley Online Library
Oncostatin M (OSM) is a pleiotropic cytokine of the IL‐6 family and displays both pro‐
inflammatory and anti‐inflammatory activities. We studied the impact of OSM on the gene …
inflammatory and anti‐inflammatory activities. We studied the impact of OSM on the gene …
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway
J Yang, G Chen, T Fan, X Qu - JOR spine, 2024 - Wiley Online Library
Background M1 macrophages (Mφs) are involved in osteogenic differentiation of
ligamentum flavum (LF) cells and play an important role in heterotopic ossification. However …
ligamentum flavum (LF) cells and play an important role in heterotopic ossification. However …
Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling …
WQ Li, F Dehnade, M Zafarullah - The Journal of Immunology, 2001 - journals.aai.org
Oncostatin M (OSM), a member of the IL-6 superfamily of cytokines, is elevated in patients
with rheumatoid arthritis and, in synergy with IL-1, promotes cartilage degeneration by matrix …
with rheumatoid arthritis and, in synergy with IL-1, promotes cartilage degeneration by matrix …
Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures
U Fearon, R Mullan, T Markham… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To investigate the role of oncostatin M (OSM) in cell adhesion, angiogenesis, and
matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage …
matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage …
Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts
JA Hamilton, T Leizer, DS Piccoli, KM Royston… - Biochemical and …, 1991 - Elsevier
Cytokine regulation of synovial cell function has been considered to be involved in the
pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u …
pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u …
Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-β via suppression of p44/p42 MAP kinase and JNK in osteoblasts
T Doi, T Hioki, J Tachi, K Ueda… - Biomedical …, 2022 - jstage.jst.go.jp
Bone fracture is an important trauma frequently encountered into emergency medicine as
well as orthopedics reflecting an aging society. Oncostatin M, an inflammatory cytokine …
well as orthopedics reflecting an aging society. Oncostatin M, an inflammatory cytokine …
Oncostatin M–induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT‐1 and STAT‐3 signaling: An implication for the pathogenesis of …
SH Kok, CY Hong, MYP Kuo, CC Wang… - Arthritis & …, 2009 - Wiley Online Library
Objective To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic
cells and their influences on arthritis development. Methods The expression of CCL2 in …
cells and their influences on arthritis development. Methods The expression of CCL2 in …
Amelioration of arthritis in two murine models using antibodies to oncostatin M
C Plater‐Zyberk, J Buckton, S Thompson… - Arthritis & …, 2001 - Wiley Online Library
Abstract Objective Oncostatin M (OSM) is a member of the interleukin‐6 cytokine family, with
well‐documented effects on cell growth and differentiation. OSM also has proinflammatory …
well‐documented effects on cell growth and differentiation. OSM also has proinflammatory …
Role of placenta growth factor and its receptor flt‐1 in rheumatoid inflammation: a link between angiogenesis and inflammation
Objective To investigate the direct effects of placenta growth factor (PlGF) and its specific
receptor, flt‐1, which are known to mediate angiogenesis, on the inflammatory process of …
receptor, flt‐1, which are known to mediate angiogenesis, on the inflammatory process of …