Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts

HJ Tu, TH Lin, YC Chiu, CH Tang… - Journal of cellular …, 2013 - Wiley Online Library
Oncostatin M (OSM) belongs to IL‐6 subfamily and is mostly produced by T lymphocytes.
High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it …

Oncostatin M decreases interleukin‐1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo

A Dumas, S Lagarde, C Laflamme… - Journal of cellular and …, 2012 - Wiley Online Library
Oncostatin M (OSM) is a pleiotropic cytokine of the IL‐6 family and displays both pro‐
inflammatory and anti‐inflammatory activities. We studied the impact of OSM on the gene …

M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway

J Yang, G Chen, T Fan, X Qu - JOR spine, 2024 - Wiley Online Library
Background M1 macrophages (Mφs) are involved in osteogenic differentiation of
ligamentum flavum (LF) cells and play an important role in heterotopic ossification. However …

Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling …

WQ Li, F Dehnade, M Zafarullah - The Journal of Immunology, 2001 - journals.aai.org
Oncostatin M (OSM), a member of the IL-6 superfamily of cytokines, is elevated in patients
with rheumatoid arthritis and, in synergy with IL-1, promotes cartilage degeneration by matrix …

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures

U Fearon, R Mullan, T Markham… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To investigate the role of oncostatin M (OSM) in cell adhesion, angiogenesis, and
matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage …

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts

JA Hamilton, T Leizer, DS Piccoli, KM Royston… - Biochemical and …, 1991 - Elsevier
Cytokine regulation of synovial cell function has been considered to be involved in the
pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u …

Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-β via suppression of p44/p42 MAP kinase and JNK in osteoblasts

T Doi, T Hioki, J Tachi, K Ueda… - Biomedical …, 2022 - jstage.jst.go.jp
Bone fracture is an important trauma frequently encountered into emergency medicine as
well as orthopedics reflecting an aging society. Oncostatin M, an inflammatory cytokine …

Oncostatin M–induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT‐1 and STAT‐3 signaling: An implication for the pathogenesis of …

SH Kok, CY Hong, MYP Kuo, CC Wang… - Arthritis & …, 2009 - Wiley Online Library
Objective To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic
cells and their influences on arthritis development. Methods The expression of CCL2 in …

Amelioration of arthritis in two murine models using antibodies to oncostatin M

C Plater‐Zyberk, J Buckton, S Thompson… - Arthritis & …, 2001 - Wiley Online Library
Abstract Objective Oncostatin M (OSM) is a member of the interleukin‐6 cytokine family, with
well‐documented effects on cell growth and differentiation. OSM also has proinflammatory …

Role of placenta growth factor and its receptor flt‐1 in rheumatoid inflammation: a link between angiogenesis and inflammation

SA Yoo, HJ Yoon, HS Kim, CB Chae… - … : Official Journal of …, 2009 - Wiley Online Library
Objective To investigate the direct effects of placenta growth factor (PlGF) and its specific
receptor, flt‐1, which are known to mediate angiogenesis, on the inflammatory process of …