Background Tacrolimus is a common immunosuppressive for transplantation. The enzyme
encoded by the CYP3A5 gene can regulate the metabolism of tacrolimus, and the …

Background Tacrolimus is essential for the maintenance of immunosuppression after a
kidney transplant. CYP3A5 is the gene that metabolizes tacrolimus, and polymorphism in …

Introduction: Although the association between CYP3A5 gene polymorphism and tacrolimus
dosing requirements was well established, the impact on how CYP3A5 genotype affects the …

Background This study aims to investigate the frequencies and association of CYP3A5
polymorphism with tacrolimus concentration among renal transplant recipients in Vietnam …

Aim: Meta-analyses and large cohort studies provide confusing results on the association of
the CYP3A5 6986A> G allelic variant and adverse outcomes in kidney transplant recipients …

Background Genetic polymorphism is an important factor that influences tacrolimus
concentrations and has the potential to predict the optimal dosage of tacrolimus in …

Aims: The calcineurin inhibitors cyclosporine and tacrolimus are the major
immunosuppressive agents, It becomes complicated to use them for their interindividual …

The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of
kidney transplant patients. This variability has been attributed to the genetic polymorphism of …

BACKGROUND AND AIMS: Variability in CYP3A5 expression associated with differences in
tacrolimus bioavailability has been documented. The wild-type allele CYP3A5* 1 expresses …

Background Previous reports have established that patient CYP3A5 allelic variability may be
the most important genetic contributor to interindividual variation in tacrolimus exposure in …