RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …

Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics,
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …

The era of nucleic acid nanomedicine has arrived, as evidenced by Patisiran, a small
interfering RNA (siRNA) encapsulated lipid nanoparticle (LNP), and mRNA-loaded LNPs …

The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …

The efforts made to develop RNAi‐based therapies have led to productive research in the
field of infections in humans, such as hepatitis C virus (HCV), hepatitis B virus (HBV), human …

Introduction: Lipid nanoparticles (LNP) have been successfully used as a platform
technology for delivering nucleic acids to the liver. To broaden the application of LNPs in …

Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …