Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-
inflammatory innate immune responses, but its significance in non-infectious diseases …

Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous
studies found that the expression of triggering receptor expressed on myeloid cells 2 …

Atherosclerosis is driven by the expansion of cholesterol-loaded 'foamy'macrophages in the
arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque …

Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in
cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal …

Background Genomic profiling of lesional and nonlesional skin of patients with atopic
dermatitis (AD) using microarrays has led to increased understanding of AD and …

Immune cells residing in white adipose tissue have been highlighted as important factors
contributing to the pathogenesis of metabolic diseases, but the molecular regulators that …

Macrophages play a major role in the pathogenesis of atherosclerosis. Many studies have
shone light on the different phenotypes and functions that macrophages can acquire upon …

The regulation of cutaneous inflammatory processes is essential for the human skin to
maintain homeostasis in the presence of the dense communities of resident microbes that …

Background & Aims Previous single-cell RNA-sequencing analyses have shown that Trem2-
expressing macrophages are present in the liver during obesity, non-alcoholic …