Lymph node metastases in cancer patients are associated with tumor aggressiveness,
poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in …

Treatment of stage IV cancer, when metastases are detectable by conventional imaging
methods, is commonly the only strategy we have to defend against this lethal stage of …

PERSPECTIVES normal mammary epithelial cells injected into the mouse bloodstream
survived for prolonged periods in the lungs, proliferated there, and could form mammary …

Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic
aspects of the disease. Building on new mechanistic insights emerging from recent …

When do cancer cells acquire metastatic identity? Recent reports have indicated that the
propensity to metastasize might be hardwired early during tumor development. Now it …

Despite decades of study, there are still many unanswered questions about metastasis, the
process by which a localized cancer becomes a systemic disease. One of these questions is …

The immune system plays an important role in regulating tumor growth and metastasis.
Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical …

INTRODUCTION Cancer progression is fundamentally an evolutionary process, involving
multiple distinct steps from oncogenic transformation to metastatic dissemination to …

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant. Metastasis-initiating cells are …

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