Understanding the intricate relationships between gene expression levels and epigenetic
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …

The promise of epigenome-wide association studies and cancer-specific somatic DNA
methylation changes in improving our understanding of cancer, coupled with the decreasing …

Background High-throughput DNA methylation arrays are likely to accelerate the pace of
methylation biomarker discovery for a wide variety of diseases. A potential problem with a …

DBCAT (database of CpG islands and analytical tools, http://dbcat. cgm. ntu. edu. tw/),
developed to characterize comprehensive DNA methylation profiles in human cancers, is a …

The haploid human genome contains approximately 29 million CpGs that exist in a
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …

Recent technology has made it possible to measure DNA methylation profiles in a cost-
effective and comprehensive genome-wide manner using array-based technology for …

Epigenome-wide association studies (EWASs) have become increasingly popular for
studying DNA methylation (DNAm) variations in complex diseases. The Illumina methylation …

DNA methylation is among the most studied epigenetic modifications in eukaryotes. The
interest in DNA methylation stems from its role in development, as well as its wellestablished …

Background Recent progress in high-throughput technologies has greatly contributed to the
development of DNA methylation profiling. Although there are several reports that describe …

We have developed a high-throughput method for analyzing the methylation status of
hundreds of preselected genes simultaneously and have applied it to the discovery of …