Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a …
KH Mayer, JM Molina, MA Thompson, PL Anderson… - The Lancet, 2020 - thelancet.com
Background Tenofovir alafenamide shows high antiviral efficacy and improved renal and
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week …
O Ogbuagu, PJ Ruane, D Podzamczer, LC Salazar… - The Lancet …, 2021 - thelancet.com
Background In DISCOVER, a multinational, randomised controlled trial, emtricitabine and
tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate …
tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate …
Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double …
Background Antiretroviral pre-exposure prophylaxis (PrEP), with daily oral tenofovir
disoproxil fumarate or tenofovir disoproxil fumarate in combination with emtricitabine, has …
disoproxil fumarate or tenofovir disoproxil fumarate in combination with emtricitabine, has …
On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a …
G Antoni, C Tremblay, C Delaugerre, I Charreau… - The lancet HIV, 2020 - thelancet.com
Background ANRS IPERGAY found that on-demand pre-exposure prophylaxis (PrEP) with
oral tenofovir disoproxil fumarate plus emtricitabine was associated with an 86% relative …
oral tenofovir disoproxil fumarate plus emtricitabine was associated with an 86% relative …
[HTML][HTML] Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label …
S McCormack, DT Dunn, M Desai, DI Dolling, M Gafos… - The Lancet, 2016 - thelancet.com
Background Randomised placebo-controlled trials have shown that daily oral pre-exposure
prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection. However …
prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection. However …
Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study
JM Molina, J Ghosn, L Assoumou, C Delaugerre… - The lancet HIV, 2022 - thelancet.com
Background There are few data available regarding the use of on-demand pre-exposure
prophylaxis (PrEP) for HIV prevention. We aimed to assess PrEP effectiveness, adherence …
prophylaxis (PrEP) for HIV prevention. We aimed to assess PrEP effectiveness, adherence …
Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men
PL Anderson, DV Glidden, A Liu… - Science translational …, 2012 - science.org
Drug concentrations associated with protection from HIV-1 acquisition have not been
determined. We evaluated drug concentrations among men who have sex with men in a …
determined. We evaluated drug concentrations among men who have sex with men in a …
Pre-exposure prophylaxis 2.0: new drugs and technologies in the pipeline
Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine was
adopted by WHO as a strategy to reduce HIV incidence. Although shown to be highly …
adopted by WHO as a strategy to reduce HIV incidence. Although shown to be highly …
HIV pre-exposure prophylaxis in men who have sex with men and transgender women: a secondary analysis of a phase 3 randomised controlled efficacy trial
SP Buchbinder, DV Glidden, AY Liu… - The Lancet infectious …, 2014 - thelancet.com
Background For maximum effect pre-exposure prophylaxis should be targeted to the
subpopulations that account for the largest proportion of infections (population-attributable …
subpopulations that account for the largest proportion of infections (population-attributable …
[HTML][HTML] Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study
Background Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We
implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour …
implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour …