Background Findings of historical studies suggest that elevated LDL cholesterol is not
associated with increased risk of myocardial infarction and atherosclerotic cardiovascular …

Background The impact of total serum cholesterol as a risk factor for cardiovascular disease
decreases with age, which casts doubt on the necessity for cholesterol-lowering therapy in …

Background The clinical benefit of LDL cholesterol lowering treatment in older patients
remains debated. We aimed to summarise the evidence of LDL cholesterol lowering …

Objective It is well known that total cholesterol becomes less of a risk factor or not at all for all-
cause and cardiovascular (CV) mortality with increasing age, but as little is known as to …

Background: Low-density lipoprotein cholesterol (LDL-C) is an important causal risk factor
for atherosclerotic cardiovascular disease (ASCVD). However, a sizable proportion of …

Background A generally held belief is that cholesterol concentrations should be kept low to
lessen the risk of cardiovascular disease. However, studies of the relation between serum …

Importance While statin therapy for primary cardiovascular prevention has been associated
with reductions in cardiovascular morbidity, the effect on all-cause mortality has been …

Importance Low-density lipoprotein cholesterol (LDL-C) is a major risk factor for
cardiovascular disease (CVD). Most observational studies on the association between LDL …

Background Statin therapy has been shown to reduce major vascular events and vascular
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …

ContextBased on observational and interventional data for middle-aged cohorts (aged 40-
64 years), serum cholesterol level is known to be an established major risk factor for …