Chemoresistance in pancreatic ductal adenocarcinoma: Overcoming resistance to therapy

P Bhoopathi, P Mannangatti, SK Das, PB Fisher… - Advances in Cancer …, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), a prominent cause of cancer deaths worldwide,
is a highly aggressive cancer most frequently detected at an advanced stage that limits …

[HTML][HTML] The challenge of drug resistance in pancreatic ductal adenocarcinoma: a current overview

F Quiñonero, C Mesas, K Doello, L Cabeza… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates among all
cancer types. Its delayed diagnosis precludes curative resection, thus most of the current …

[HTML][HTML] Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities

A Jain, V Bhardwaj - World journal of gastroenterology, 2021 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related
deaths in the United States. Although chemotherapeutic regimens such as gemcitabine+ …

The biological underpinnings of therapeutic resistance in pancreatic cancer

GL Beatty, G Werba, CA Lyssiotis… - Genes & …, 2021 - genesdev.cshlp.org
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal …

Mechanisms of drug resistance of pancreatic ductal adenocarcinoma at different levels

J Du, J Gu, J Li - Bioscience Reports, 2020 - portlandpress.com
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related
death worldwide, and the mortality of patients with PDAC has not significantly decreased …

Unveiling the Resistance to Therapies in Pancreatic Ductal Adenocarcinoma

A Shah, K Ganguly, S Rauth, SS Sheree, I Khan… - Drug Resistance …, 2024 - Elsevier
Despite the ongoing advances in interventional strategies (surgery, chemotherapy,
radiotherapy, and immunotherapy) for managing pancreatic ductal adenocarcinoma …

[HTML][HTML] The landscape of pancreatic cancer therapeutic resistance mechanisms

S Chand, K O'Hayer, FF Blanco, JM Winter… - International journal of …, 2016 - ncbi.nlm.nih.gov
Pancreatic cancer (pancreatic ductal adenocarcinoma, PDA) is infamously moving to the top
of the list as one of the most lethal cancers with an overall 5 year survival rate of 7%. Multiple …

Drug resistance in pancreatic cancer: New player caught in act

G Capurso, C Sette - EBioMedicine, 2019 - thelancet.com
Most human cancers display high levels of heterogeneity, a feature that often impacts
negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially …

Chemoresistance in pancreatic cancer

S Zeng, M Pöttler, B Lan, R Grützmann… - International journal of …, 2019 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC),
ranks the fourth leading cause of cancer-related deaths in the western world. While the …

CYP3A5 contributes to PDAC chemoresistance

H Thomas - Nature Reviews Gastroenterology & Hepatology, 2016 - nature.com
New research sheds light on the mechanisms underlying resistance to chemotherapeutics in
patients with pancreatic ductal adenocarcinoma (PDAC). Increased expression of CYP3A5 …