Near-infrared photosensitizers adaptive to tumor hypoxic microenvironment for synergistic photothermal-photodynamic and immunotherapy

X Meng, Y Han, S Wang, X Wang, Z Zhang, S Yao… - Nano Today, 2023 - Elsevier
For photodynamic therapy (PDT), traditional type II photosensitizers rely on local molecular
oxygen to produce highly cytotoxic singlet oxygen (1 O 2) to kill tumor cells, which is …

Tumor microenvironment-responsive nanohybrid for hypoxia amelioration with photodynamic and near-infrared II photothermal combination therapy

P Zhang, Q Wu, J Yang, M Hou, B Zheng, J Xu, Y Chai… - Acta Biomaterialia, 2022 - Elsevier
Phototherapy, particularly photothermal therapy (PTT) and photodynamic therapy (PDT), has
been widely investigated for tumor treatment. However, the limited tissue penetration depth …

NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy

H Chen, T Sun, W Zeng, X Zeng, L Mei… - ACS Materials …, 2021 - ACS Publications
Despite the fact that photodynamic therapy (PDT) has promising clinical prospects, its
therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME) …

Acidic TME‐Responsive Nano‐Bi2Se3@MnCaP as a NIR‐II‐Triggered Free Radical Generator for Hypoxia‐Irrelevant Phototherapy with High Specificity and …

Y Li, H Yu, J Ren, G Lu, Y Cao, Z Xu, Y Kang, P Xue - Small, 2022 - Wiley Online Library
Here, acidic tumor microenvironment (TME)‐responsive nano‐Bi2Se3@ MnCaP, as a near‐
infrared‐II (NIR‐II) biowindow‐triggered free radical generator for hypoxia‑irrelevant …

A targeted phototheranostic agent with strong AIE effect and boosted type I ROS generation

Y Wang, C Zhang, Y Li, R Li, J Li, L Feng - Dyes and Pigments, 2023 - Elsevier
Hypoxia and nonspecific killing always hinder the photodynamic therapy of malignant
tumors and infectious diseases that both severely threatening human health. Herein, we …

Controllable hypoxia-activated chemotherapy as a dual enhancer for synergistic cancer photodynamic immunotherapy

M Wang, M He, M Zhang, S Xue, T Xu, Y Zhao, D Li… - Biomaterials, 2023 - Elsevier
The efficacy of photodynamic therapy (PDT) is severely limited by the hypoxic tumor
microenvironment (TME), while the performance of PDT-aroused antitumor immunity is …

Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity

D Chen, Y Tang, J Zhu, J Zhang, X Song, W Wang… - Biomaterials, 2019 - Elsevier
Highly specific and effective cancer phototherapy remains as a great challenge. Herein, a
smart nanoplatform (TENAB NP) sequentially responsive to light, low pH and hypoxia is …

Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation

Y Zhou, X Ren, Z Hou, N Wang, Y Jiang, Y Luan - Nanoscale horizons, 2021 - pubs.rsc.org
Photosensitizer-based photodynamic therapy (PDT) can not only kill tumor cells by the
generated cytotoxic reactive oxygen species (ROS), but also trigger immunogenic cell death …

A versatile near infrared light triggered dual-photosensitizer for synchronous bioimaging and photodynamic therapy

L Feng, F He, Y Dai, B Liu, G Yang, S Gai… - … Applied Materials & …, 2017 - ACS Publications
Photodynamic therapy (PDT) based on Tm3+-activated up-conversion nanoparticles
(UCNPs) can effectively eliminate tumor cells by triggering inorganic photosensitizers to …

Gold nanobipyramid@ copper sulfide nanotheranostics for image-guided NIR-II photo/chemodynamic cancer therapy with enhanced immune response

Y Chen, P Liu, C Zhou, T Zhang, T Zhou, D Men… - Acta Biomaterialia, 2023 - Elsevier
Photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy
(CDT) can cause cancer cell death through an immunogenic process. However, the study of …