[HTML][HTML] MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

M Aichler, A Walch - Laboratory investigation, 2015 - Elsevier
MALDI Imaging mass spectrometry has entered the field of tissue-based research by
providing unique advantages for analyzing tissue specimen in an unprecedented detail. A …

New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry

P Chaurand, JL Norris, DS Cornett… - Journal of proteome …, 2006 - ACS Publications
Molecular imaging of tissue by MALDI mass spectrometry is a powerful tool for visualizing
the spatial distribution of constituent analytes with high molecular specificity. Although the …

MALDI imaging mass spectrometry in cancer research: combining proteomic profiling and histological evaluation

C Schöne, H Höfler, A Walch - Clinical biochemistry, 2013 - Elsevier
Despite the tendency to regard tumors as a simple mass of cancer cells, tumors have a high
degree of complexity that is difficult to access with most analytical methods. Because the …

[HTML][HTML] MALDI imaging mass spectrometry: state of the art technology in clinical proteomics

J Franck, K Arafah, M Elayed, D Bonnel… - Molecular & Cellular …, 2009 - ASBMB
A decade after its inception, MALDI imaging mass spectrometry has become a unique
technique in the proteomics arsenal for biomarker hunting in a variety of diseases. At this …

MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives

EH Seeley, RM Caprioli - Trends in biotechnology, 2011 - cell.com
The molecular complexity of biological tissue and the spatial and temporal variation in the
biological processes involved in human disease requires new technologies and new …

[HTML][HTML] MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology

A Walch, S Rauser, SO Deininger, H Höfler - Histochemistry and cell …, 2008 - Springer
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful tool for investigating the distribution of proteins and small molecules within …

[HTML][HTML] MALDI imaging mass spectrometry–painting molecular pictures

K Schwamborn, RM Caprioli - Molecular oncology, 2010 - Elsevier
MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of
simultaneously measuring multiple analytes directly from intact tissue sections. Histological …

Imaging mass spectrometry: a new tool for pathology in a molecular age

JL Norris, RM Caprioli - PROTEOMICS–Clinical Applications, 2013 - Wiley Online Library
Mass spectrometry (MS) provides unique advantages for the analysis of clinical specimens,
and these capabilities have been critical to the advancement of diagnostic medicine. To …

[HTML][HTML] Tissue profiling by mass spectrometry: a review of methodology and applications

RL Caldwell, RM Caprioli - Molecular & Cellular Proteomics, 2005 - ASBMB
Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) has become a
valuable tool to address a broad range of questions in many areas of biomedical research …

MALDI imaging mass spectrometry—from bench to bedside

K Schwamborn, M Kriegsmann, W Weichert - Biochimica et Biophysica Acta …, 2017 - Elsevier
Today, pathologists face many challenges in defining the precise morphomolecular
diagnosis and in guiding clinicians to the optimal patients' treatment. To achieve this goal …