Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
ED Michelakis, V Gurtu, L Webster, G Barnes… - Science translational …, 2017 - science.org
Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high
mortality rate. It is characterized by an occlusive vascular remodeling due to a pro …
mortality rate. It is characterized by an occlusive vascular remodeling due to a pro …
Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
[HTML][HTML] The metabolic basis of pulmonary arterial hypertension
G Sutendra, ED Michelakis - Cell metabolism, 2014 - cell.com
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs
resulting in heart failure and premature death. Although, until recently, it was thought that …
resulting in heart failure and premature death. Although, until recently, it was thought that …
[HTML][HTML] The role of mitochondria in pulmonary vascular remodeling
Pulmonary arterial hypertension (PAH) is characterized by a hyperproliferative and anti-
apoptotic diathesis within the vascular wall of the resistance pulmonary arteries, leading to …
apoptotic diathesis within the vascular wall of the resistance pulmonary arteries, leading to …
Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and …
Mitochondria are central to cellular metabolism. The metabolic pathways of mitochondria
include fatty acid oxidation, glucose oxidation, and glutaminolysis. The initial step in glucose …
include fatty acid oxidation, glucose oxidation, and glutaminolysis. The initial step in glucose …
[HTML][HTML] Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by
enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells …
enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells …
The metabolic theory of pulmonary arterial hypertension
R Paulin, ED Michelakis - Circulation research, 2014 - Am Heart Assoc
Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
[HTML][HTML] Translational Advances in the Field of Pulmonary Hypertension.From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting …
Pulmonary arterial hypertension (PAH) has been frequently compared with a type of
malignant disease and has an incredible number of pathogenic mechanisms similar to …
malignant disease and has an incredible number of pathogenic mechanisms similar to …
[HTML][HTML] Mitochondrial dynamics in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is an idiopathic cardiopulmonary disease
characterized by obstruction of small pulmonary arteries. Vascular obstruction is the …
characterized by obstruction of small pulmonary arteries. Vascular obstruction is the …
[HTML][HTML] Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans
R Paulin, P Dromparis, G Sutendra, V Gurtu… - Cell metabolism, 2014 - cell.com
Suppression of mitochondrial function promoting proliferation and apoptosis suppression
has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary …
has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary …