Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

M Hu, Y Zhang, S Ma, J Li, X Wang… - Molecular human …, 2021 - academic.oup.com
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the
increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain …

Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

Y Zhang, M Hu, W Jia, G Liu, J Zhang… - Journal of …, 2020 - joe.bioscientifica.com
Women with polycystic ovary syndrome (PCOS) have hyperandrogenism and insulin
resistance and a high risk of miscarriage during pregnancy. Similarly, in rats, maternal …

Hyperandrogenism and insulin resistance‐induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in …

Y Zhang, W Zhao, H Xu, M Hu, X Guo… - The Journal of …, 2019 - Wiley Online Library
Key points Women with polycystic ovary syndrome (PCOS) commonly suffer from
miscarriage, but the underlying mechanisms remain unknown. Herein, pregnant rats …

Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production

M Hu, Y Zhang, X Guo, W Jia, G Liu… - American Journal …, 2019 - journals.physiology.org
Women with polycystic ovary syndrome (PCOS) are at increased risk of miscarriage, which
often accompanies the hyperandrogenism and insulin resistance seen in these patients …

[Retracted] Cryptotanshinone Protects against PCOS‐Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential …

H Liu, J Xie, L Fan, Y Xia, X Peng… - … Medicine and Cellular …, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
childbearing age. Cryptotanshinone (CRY) has been shown to be effective in reversing …

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis

Y Sun, M Sha, Y Qin, J Xiao, W Li, S Li… - Free Radical Biology and …, 2024 - Elsevier
Exposure to bisphenol A (BPA) during gestation leads to fetal growth restriction (FGR),
whereby the underlying mechanisms remain unknown. Here, we found that FGR patients …

[HTML][HTML] Decidual stromal cell ferroptosis associated with abnormal iron metabolism is implicated in the pathogenesis of recurrent pregnancy loss

F Sun, L Cui, J Qian, M Li, L Chen, C Chen… - International Journal of …, 2023 - mdpi.com
Iron is necessary for various critical biological processes, but iron overload is also
dangerous since labile iron is redox-active and toxic. We found that low serum iron and …

[HTML][HTML] Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation

Q Shi, R Liu, L Chen - Molecular Medicine Reports, 2022 - spandidos-publications.com
Polycystic ovary syndrome is one of the most common endocrine and metabolic
gynecological disorders, of which dysfunction of ovarian granulosa cells is a key contributing …

[HTML][HTML] The emerging role of ferroptosis in female reproductive disorders

M Liu, K Wu, Y Wu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Iron, as an essential trace element for the organism, is vital for maintaining the organism's
health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus …

[HTML][HTML] Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin

R Du, X Cheng, J Ji, Y Lu, Y Xie, W Wang, Y Xu… - Scientific Reports, 2023 - nature.com
Ferroptosis is widely present in fibrosis-related diseases. The basic pathology of premature
ovarian insufficiency (POI) involves ovarian tissue fibrosis, and there are currently fewer …