CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

EJ Petrie, CS Clements, J Lin, LC Sullivan… - The Journal of …, 2008 - rupress.org
The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2
natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor …

Structural basis for NKG2A/CD94 recognition of HLA-E

BK Kaiser, JC Pizarro, J Kerns… - Proceedings of the …, 2008 - National Acad Sciences
The NKG2x/CD94 (x= A, C, E) natural killer-cell receptors perform an important role in
immunosurveillance by binding to HLA-E complexes that exclusively present peptides …

The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition

LC Sullivan, CS Clements, T Beddoe, D Johnson… - Immunity, 2007 - cell.com
The CD94-NKG2 receptor family that regulates NK and T cells is unique among the lectin-
like receptors encoded within the natural killer cell complex. The function of the CD94-NKG2 …

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94–NKG2 natural killer cell receptors

HL Hoare, LC Sullivan, CS Clements, LK Ely… - Journal of molecular …, 2008 - Elsevier
Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I
molecule that binds peptides derived from the leader sequences of other HLA class I …

HLA‐E‐bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA‐G‐derived nonamer

M Llano, N Lee, F Navarro, P García… - European journal of …, 1998 - Wiley Online Library
Abstract The HLA‐E class Ib molecule constitutes a major ligand for the lectin‐like
CD94/NKG2 natural killer (NK) cell receptors. Specific HLA class I leader sequence‐derived …

Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2

JD Miller, DA Weber, C Ibegbu, J Pohl… - The Journal of …, 2003 - journals.aai.org
The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory
receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition …

The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA‐E through mostly shared but partly distinct sets of HLA‐E …

H Wada, N Matsumoto, K Maenaka… - European journal of …, 2004 - Wiley Online Library
The human non‐classical MHC class I molecule HLA‐E is a ligand for both an inhibitory NK
cell receptor (CD94/NKG2A) and an activating receptor (CD94/NKG2C). To identify HLA‐E …

Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics

BK Kaiser, F Barahmand-Pour, W Paulsene… - The Journal of …, 2005 - journals.aai.org
The NKG2x/CD94 family of C-type lectin-like immunoreceptors (x= A, B, C, E, and H)
mediates surveillance of MHC class Ia cell surface expression, often dysregulated during …

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

BD Huisman, N Guan, T Rückert, L Garner… - Nature …, 2023 - nature.com
HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune
recognition. While recent studies have shown HLA-E can present diverse peptides to NK …

HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Z Lin, AA Bashirova, M Viard, L Garner, M Quastel… - Nature …, 2023 - nature.com
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …