Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Classical activation of macrophages (M (LPS+ IFNγ)) elicits the expression of inducible nitric
oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial …

M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms
mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) …

Macrophages are found in most tissues of the body, where they have tissue-and context-
dependent roles in maintaining homeostasis as well as coordinating adaptive responses to …

Energy metabolism and redox state are intrinsically linked. In order to mount an adequate
immune response, cells must have an adequate and rapidly available energy resource to …

Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …

Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that
is only partially understood. By using an integrated high-throughput transcriptional …

Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

Metabolic reprogramming is implicated in macrophage activation, but the underlying
mechanisms are poorly understood. Here, we demonstrate that the NOTCH1 pathway …

Macrophages display a spectrum of functional activation phenotypes depending on the
composition of the microenvironment they reside in, including type of tissue/organ and …