Cinchona alkaloids in asymmetric organocatalysis

T Marcelli, H Hiemstra - Synthesis, 2010 - thieme-connect.com
This article reviews the applications of cinchona alkaloids as asymmetric catalysts. In the last
few years, characterized by the resurgence of interest in asymmetric organocatalysis …

Cinchona alkaloids and their derivatives: versatile catalysts and ligands in asymmetric synthesis

K Kacprzak, J Gawroński - Synthesis, 2001 - thieme-connect.com
Cinchona alkaloids and their derivatives can catalyze an amazing array of synthetically
important reactions, providing access to chiral products of high enantiopurity. A review of …

Asymmetric organocatalysis mediated by primary amines derived from cinchona alkaloids: recent advances

J Duan, P Li - Catalysis Science & Technology, 2014 - pubs.rsc.org
Primary amine catalysts derived from cinchona alkaloids have emerged as readily available,
highly versatile and extremely powerful catalysts in asymmetric synthesis. In particular, they …

Origin of and a solution for uneven efficiency by cinchona alkaloid-derived, pseudoenantiomeric catalysts for asymmetric reactions

B Hu, MW Bezpalko, C Fei, DA Dickie… - Journal of the …, 2018 - ACS Publications
Cinchona alkaloid-derived chiral catalysts represent one of the most widely applied classes
of organocatalysts, which have been successfully utilized in the promotion of a wide variety …

Nucleophilic chiral amines as catalysts in asymmetric synthesis

S France, DJ Guerin, SJ Miller, T Lectka - Chemical reviews, 2003 - ACS Publications
Catalytic asymmetric synthesis is providing chemists with new and powerful tools for the
efficient synthesis of complex molecules. While many of the most notable catalytic systems …

Asymmetric catalysis with bifunctional cinchona alkaloid-based urea and thiourea organocatalysts

SJ Connon - Chemical communications, 2008 - pubs.rsc.org
Cinchona alkaloid derivatives modified to include a (thio) urea component have emerged in
the last three years as readily accessible, robust and tunable bifunctional organocatalysts for …

Recent applications of Cinchona alkaloids and their derivatives as catalysts in metal-free asymmetric synthesis

EMO Yeboah, SO Yeboah, GS Singh - Tetrahedron, 2011 - Elsevier
The Cinchona alkaloids are natural products found in the bark of trees of the genus
Cinchona. The genus comprises about 40 species of trees or shrubs in the family Rubiaceae …

Bifunctional catalysis by natural Cinchona alkaloids: a mechanism explained

CS Cucinotta, M Kosa, P Melchiorre… - … A European Journal, 2009 - Wiley Online Library
The use of bifunctional chiral catalysts, which are able to simultaneously bind and activate
two reacting partners, currently represents an efficient and reliable strategy for the …

Cupreines and cupreidines: An emerging class of bifunctional cinchona organocatalysts

T Marcelli, JH van Maarseveen… - Angewandte Chemie …, 2006 - Wiley Online Library
In the steadily expanding field of organocatalysis, cinchona alkaloids play a prominent role.
Until the late 1990s, bifunctional catalysts based on this scaffold relied exclusively on the C9 …

Role of cinchona alkaloids in the enantio-and diastereoselective synthesis of axially chiral compounds

C Portolani, G Centonze, P Righi… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Asymmetric synthesis using organic catalysts has evolved since it was first
realized and defined. Nowadays, it can be considered a valid alternative to transition metal …