Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic
obstructive pulmonary disease (COPD). Computed tomography densitometry has been …

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation, caused by emphysema and small airways disease (SAD). Computed tomography …

Rationale and Objectives The longitudinal relationship between regional air trapping and
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …

Rationale: The small conducting airways are the major site of airflow obstruction in chronic
obstructive pulmonary disease and may precede emphysema development. Objectives: We …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized
by both small airway and parenchymal abnormalities. There is increasing evidence to …

Background: Disease accumulates in the small airways without being detected by
conventional measurements. Objectives: To quantify small airway disease using a novel …

Background In the search for specific phenotypes of chronic obstructive pulmonary disease
(COPD) computed tomography (CT) derived Parametric Response Mapping (PRM) has …

Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …

Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD)
renders identifying different trajectories of disease progression challenging. Objectives: To …

Rationale: The predominant cause of chronic lung allograft failure is small airway
obstruction arising from bronchiolitis obliterans. However, clinical methodologies for …