Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …

Innate immune response acts as the first line of host defense against damage and is initiated
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …

Background Neuroinflammation in the peripheral nervous system has been linked to cancer
metastasis-induced bone pain. The stimulator of interferon genes (STING), an innate …

Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI).
PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic …

Background Patients receiving epidural or intrathecal opioids administration for neuraxial
analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an …

Simple Summary Cancer-induced bone pain commonly occurs in patients with bone tumors
or bone metastases, and in recent years, central nervous system hyperalgesia has received …

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …

Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via
MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of …

Inflammation and pain are intertwined responses to injury, infection, or chronic diseases.
While acute inflammation is essential in determining pain resolution and opioid analgesia …

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by
cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral …