The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

Activation of the immune system in heart failure (HF) has been recognized for over 20 years.
Initially, experimental studies demonstrated a maladaptive role of the immune system …

The immune system is a crucial player in tissue homeostasis and wound healing. A
sophisticated cascade of events triggered upon injury ensures protection from infection and …

Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle
associated with systemic inflammation. Burgeoning evidence implicates immune effector …

Abstract Purpose of Review In heart failure, whether it is associated with reduced or
preserved ejection fraction, the immune system is activated and contributes to heart …

The increasing use of single-cell immune profiling and advanced microscopic imaging
technologies has deepened our understanding of the cardiac immune system, confirming …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Innate immunity and inflammation play key roles in a wide range of pathology–including
heart disease and vasculopathies. Current thinking suggests “damage” rather than …

Myocardial ischemia/reperfusion (I/R) is the most common cause of myocardial
inflammation, which is primarily a manifestation of the innate immune responses. Innate …