Systematic development of an UPLC–MS/MS method for the determination of tricyclic antidepressants in human urine

EE Chambers, MJ Woodcock, JP Wheaton… - … of pharmaceutical and …, 2014 - Elsevier
Tricyclic antidepressants have been prescribed for the treatment of depression and other
disorders since their discovery in the 1950s but have been replaced in recent decades by …

Monitoring of tricyclic antidepressants in human serum and plasma by HPLC: characterization of a simple, laboratory developed method via external quality …

R Theurillat, W Thormann - Journal of pharmaceutical and biomedical …, 1998 - Elsevier
A reversed-phase high performance liquid chromatography (HPLC) method for the
determination of plasma and serum levels of amitriptyline (AMI), nortriptyline (NORT) …

Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids

VF Samanidou, MK Nika… - Journal of separation …, 2007 - Wiley Online Library
A simple, rapid and sensitive HPLC method was developed and validated for the
determination of four tricyclic antidepressants (TCAs): amitriptyline, doxepin, clomipramine …

A rapid and reliable method for the quantitation of tricyclic antidepressants in serum using HPLC-MS/MS

AR Breaud, R Harlan, M Kozak, W Clarke - Clinical Biochemistry, 2009 - Elsevier
OBJECTIVE: Here we describe a liquid chromatography-tandem mass spectrometry method
for the detection of tricyclic antidepressant drugs (amitriptyline, desipramine, imipramine …

Method validation of a tricyclic antidepressant drug panel in urine by UPLC-MS/MS

CN Lin, JEM Juenke… - Annals of Clinical & …, 2014 - Assoc Clin Scientists
Tricyclic antidepressant (TCA) drugs are also used as adjunctive therapy to treat chronic
pain. To monitor patient compliance to therapy, urine specimens may be preferred since …

Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS–MS with an ion trap detector

M Kollroser, C Schober - Therapeutic drug monitoring, 2002 - journals.lww.com
A sensitive and specific direct-injection high-performance liquid chromatography–
atmospheric pressure chemical ionization tandem mass-spectrometry (HPLC-APCI-MS–MS) …

Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas …

R de la Torre, J Ortuño, JA Pascual… - Therapeutic drug …, 1998 - journals.lww.com
An analytical method for the simultaneous determination of amitriptyline, nortriptyline,
imipramine, desipramine, clomipramine, and desmethylclomipramine in human plasma …

[HTML][HTML] Determination of tricyclic antidepressants in human urine samples by the three-step sample pretreatment followed by HPLC-UV analysis: an efficient …

A Mohebbi, MA Farajzadeh, S Yaripour… - Excli Journal, 2018 - ncbi.nlm.nih.gov
In this work, an efficient sample pretreatment method has been developed by combining salt
induced-homogenous liquid-liquid extraction, dispersive solid phase extraction, and …

Detection and quantification of tricyclic antidepressants and other psychoactive drugs in urine by HPLC/MS/MS for pain management compliance testing

JL Poklis, CE Wolf, A Goldstein… - Journal of Clinical …, 2012 - Wiley Online Library
A sensitive, specific, and rapid high‐pressure liquid chromatography/mass
spectrometry/mass spectrometry method was developed for the quantitation of 11 tricyclic …

Quantification of tricyclic and nontricyclic antidepressants in spiked plasma and urine samples using microextraction in packed syringe and analysis by LC and GC-MS

S Rani, A Kumar, AK Malik, B Singh - Chromatographia, 2011 - Springer
A simple, fast, selective and very sensitive method based on sample preparation by the
relatively new technique of microextraction in a packed syringe (MEPS) and analysis by …