The mammalian striatin family consists of three proteins, striatin, S/G 2 nuclear autoantigen,
and zinedin. Striatin family members have no intrinsic catalytic activity, but rather function as …

The striatin-interacting phosphatases and kinases (STRIPAK) complex is evolutionary highly
conserved and has been structurally and functionally described in diverse lower and higher …

Striatin-interacting phosphatase and kinase (STRIPAK) complexes are striatin-centered
multicomponent supramolecular structures containing both kinases and phosphatases …

Proteins of the striatin family have been identified in all multicellular animals. They are
multidomain molecules containing several protein-interacting motifs. In mammals, these …

Background Striatin, a putative protein phosphatase 2A (PP2A) B-type regulatory subunit, is
a multi-domain scaffolding protein that has recently been linked to several diseases …

The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …

Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of
human cancers, and partial loss of PP2A function contributes to cell transformation …

Cerebral cavernous malformations (CCMs) are alterations in brain capillary architecture that
can result in neurological deficits, seizures, or stroke. We recently demonstrated that CCM3 …

The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding …

Serine/arginine protein kinases have been conserved throughout evolution and are thought
to play important roles in the regulation of mRNA processing, nuclear import, germline …