High throughput drug screening is an established approach to investigate tumor biology and
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …

Abstract Three-dimensional (3D) cell culture technologies, such as organoids, are
physiologically relevant models for basic and clinical applications. Automated microfluidics …

For drug discovery, cell-based assays are becoming increasingly complex to mimic more
realistically the nature of biological processes and their diversifications in diseases …

Variability in patient response to anti-cancer drugs is currently addressed by relating genetic
mutations to chemotherapy through precision medicine. However, practical benefits of …

3D cell culture models have been developed to better mimic the physiological environments
that exist in human diseases. As such, these models are advantageous over traditional 2D …

Image-based phenotypic screening relies on the extraction of multivariate information from
cells cultured under a large variety of conditions. Technical advances in high-throughput …

Background Patient-derived organoids are invaluable for fundamental and translational
cancer research and holds great promise for personalized medicine. However, the shortage …

Background Organoids are three-dimensional structures that closely recapitulate tissue
architecture and cellular composition, thereby holding great promise for organoid-based …

Three-quarters of compounds that enter clinical trials fail to make it to market due to safety or
efficacy concerns. This statistic strongly suggests a need for better screening methods that …

The current drug development pipeline takes approximately fifteen years and $2.6 billion to
get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures …