Aneurysms are malformations within the arterial vasculature brought on by the structural
breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

Cerebral aneurysms develop near bifurcation apices, where complex hemodynamics occur:
Flow impinges on the apex, accelerates into branches, then slows again distally, creating …

Flow impingement at arterial bifurcations causes high frictional force [or wall shear stress
(WSS)], and flow acceleration and deceleration in the branches create positive and negative …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …

Background and Purpose—Arterial bifurcation apices are common sites for cerebral
aneurysms, raising the possibility that the unique hemodynamic conditions associated with …

Little is understood about endothelial cell (EC) responses to high flow, which mediate
adaptive outward remodeling as well as cerebral aneurysm development. Opposite EC …

In the presence of tumor angiogenesis, blood flow must increase, leading to an elevation of
blood flow velocities (BFVels) and wall shear stress (WSS) in upstream native arteries. An …

Background: Intracranial aneurysms (IAs) result from abnormal enlargement of the arterial
lumen. IAs are mostly quiescent and asymptomatic, but their rupture leads to severe brain …