Correlation of blood-based immune molecules with cardiac gene expression profiles reveals insights into Chagas cardiomyopathy pathogenesis

TG Souza-Silva, EGA Neves, C Koh… - Frontiers in …, 2024 - frontiersin.org
Introduction Understanding compartmentalized immune responses in target organs is
crucial for elucidating the pathogenesis of various diseases. However, obtaining samples …

[HTML][HTML] Myocardial gene and protein expression profiles after autoimmune injury in Chagas' disease cardiomyopathy

E Cunha-Neto, PC Teixeira, SG Fonseca, AM Bilate… - Autoimmunity …, 2011 - Elsevier
One third of the 16million of individuals infected by the protozoan Trypanosoma cruzi in
Latin America eventually develop chronic Chagas' disease cardiomyopathy (CCC), an …

Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy

E Cunha-Neto, VJ Dzau, PD Allen, D Stamatiou… - The American journal of …, 2005 - Elsevier
Chronic Chagas' disease cardiomyopathy is a leading cause of congestive heart failure in
Latin America, affecting more than 3 million people. Chagas' cardiomyopathy is more …

Detecting imperative genes and infiltrating immune cells in chronic Chagas cardiomyopathy by bioinformatics analysis

L Zhou, Z Li, J Li, S Yang, H Gong - Infection, Genetics and Evolution, 2021 - Elsevier
Chronic Chagas cardiomyopathy (CCC) is an acquired inflammatory cardiomyopathy
triggered by the protozoan Trypanosoma cruzi infection. Although microvascular and …

T-cell subpopulations exhibit distinct recruitment potential, immunoregulatory profile and functional characteristics in Chagas versus idiopathic dilated …

EGA Neves, CC Koh, TG Souza-Silva… - Frontiers in …, 2022 - frontiersin.org
Chronic Chagas cardiomyopathy (CCC) is one of the deadliest cardiomyopathies known
and the most severe manifestation of Chagas disease, which is caused by infection with the …

Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy

TGM Oliveira, G Venturini, JM Alvim, LL Feijó… - Frontiers in cellular …, 2022 - frontiersin.org
Chagas disease is a tropical zoonosis caused by Trypanosoma cruzi. After infection, the
host present an acute phase, usually asymptomatic, in which an extensive parasite …

Chagas cardiomyopathy: role of sustained host-parasite interaction in systemic inflammatory burden

RA Kölliker-Frers, M Otero-Losada… - Chagas Dis.: Basic …, 2018 - books.google.com
The economic and social burden associated with Chagas disease morbidity and mortality is
regrettably large in Latin America causing more deaths than does any other parasitic …

Chagas disease cardiomyopathy: immunopathology and genetics

E Cunha-Neto, C Chevillard - Mediators of inflammation, 2014 - Wiley Online Library
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America
and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop …

Signatures of CD4+ T and B cells are associated with distinct stages of chronic chagasic cardiomyopathy

INPC Vale, GG Almeida, I Rimkute, T Liechti… - Frontiers in …, 2024 - frontiersin.org
Introduction Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi.
While most patients are asymptomatic, around 30% develop Chronic Chagasic …

Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy

E Cunha-Neto, LG Nogueira, PC Teixeira… - Memorias do Instituto …, 2009 - SciELO Brasil
The pathogenesis of Chagas disease cardiomyopathy (CCC) is not well understood. Since
studies show that myocarditis is more frequent during the advanced stages of the disease …