[HTML][HTML] CAR T-cell-associated neurotoxicity in central nervous system hematologic disease: Is it still a concern?

R Velasco, A Mussetti, M Villagrán-García… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how
clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar …

[HTML][HTML] CAR-T cells neurotoxicity from consolidated practice in hematological malignancies to fledgling experience in CNS tumors: fill the gap

L Gatto, I Ricciotti, A Tosoni, V Di Nunno… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR-T) therapy has marked a paradigm shift in the treatment of
hematological malignancies and represent a promising growing field also in solid tumors …

Neurotoxicity—CAR T-cell therapy: what the neurologist needs to know

L Neill, J Rees, C Roddie - Practical Neurology, 2020 - pn.bmj.com
Chimeric antigen receptor (CAR) T-cell therapy is one of the most innovative therapies for
haematological malignancies to emerge in a generation. Clinical studies have shown that a …

A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy.

MW Ruff, EL Siegler, SS Kenderian - Neurologic clinics, 2020 - europepmc.org
Chimeric antigen receptor-engineered T (CAR-T) cell immunotherapy has been successful
in treating many types of hematological malignancies. CAR-T therapy, however, has been …

[HTML][HTML] Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy

RC Sterner, RM Sterner - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is an emerging staple in the treatment of
certain hematological malignancies. While CAR-T cells have produced robust responses in …

Neurological updates: neurological complications of CAR-T therapy

EC Tallantyre, NA Evans, J Parry-Jones… - Journal of …, 2021 - Springer
Chimeric antigen receptor (CAR)-expressing T cells now offer an effective treatment option
for people with previously refractory B cell malignancies and are under development for a …

CAR T-cell associated neurotoxicity: mechanisms, clinicopathologic correlates, and future directions

BD Hunter, CA Jacobson - JNCI: Journal of the National Cancer …, 2019 - academic.oup.com
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary new form of
immunotherapy for the treatment of hematologic malignancies. The two primary toxicities …

How I treat unique and difficult-to-manage cases of CAR T-cell therapy–associated neurotoxicity

BD Santomasso, J Gust, F Perna - Blood, The Journal of the …, 2023 - ashpublications.org
With growing indications for chimeric antigen receptor (CAR) T-cell therapy, toxicity profiles
are evolving. There is an urgent and unmet need of approaches to optimally manage …

Neurological complications of cancer immunotherapy (CAR T cells)

DB Rubin, H Vaitkevicius - Journal of the Neurological Sciences, 2021 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy has become an indispensable tool in the
treatment of advanced malignancy, however, it is associated with significant neurologic …

Frontal predominant encephalopathy with early paligraphia as a distinctive signature of CAR T-cell therapy-related neurotoxicity

U Pensato, G Amore, R D'Angelo, R Rinaldi… - Journal of …, 2022 - Springer
Chimeric antigen receptor (CAR) T-cell therapy is an emerging highly effective treatment for
refractory haematological malignancies. Unfortunately, its therapeutic benefit may be …